(S)-(1-methyl-1H-pyrazol-5-yl)(phenyl)methanol -Drug Synthesis Database

【结构式】

【分子编号】54588

【品名】(S)-(1-methyl-1H-pyrazol-5-yl)(phenyl)methanol

【CA登记号】

【分子式】C₁₁H₁₂N₂O

【分子量】188.22916

【元素组成】C 70.19% H 6.43% N 14.88% O 8.5%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(S)-(-)-(I)

Resolution of alcohol [(±)-I] as its diastereomeric O-acetylmandelate esters and saponification of each of them in ethanol in the presence of catalytic amounts of sodium cyanide yielded the enantiomerically pure alcohols [(R)-(+)-I] and [(S)-()-I].

参考文献中间体

合成目标

【1】 Hueso, J.; Frigola, J.; Farré, A.; Berrocal, J.; Gutierrez, B.; Preparation of the enantiomers of the analgesic E-3710. Bioorg Med Chem Lett 1993, 3, 2, 269.
【2】 Farré, A.J.; Frigola, J.; Cizolirtine Citrate. Drugs Fut 2002, 27, 8, 721.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(rac)-(I)	54583	(1-methyl-1H-pyrazol-5-yl)(phenyl)methanol; 5-(alpha-hydroxybenzyl)-1-methyl-1H-pyrazole	C₁₁H₁₂N₂O	详情	详情
(R)-(+)-(I)	54587	(R)-(1-methyl-1H-pyrazol-5-yl)(phenyl)methanol	C₁₁H₁₂N₂O	详情	详情
(S)-(-)-(I)	54588	(S)-(1-methyl-1H-pyrazol-5-yl)(phenyl)methanol	C₁₁H₁₂N₂O	详情	详情

Extended Information