N,N-dimethyl-2-{[(R)-(1-methyl-1H-pyrazol-5-yl)(phenyl)methyl]oxy}-1-ethanamine; N,N-dimethyl-N-(2-{[(R)-(1-methyl-1H-pyrazol-5-yl)(phenyl)methyl]oxy}ethyl)amine -Drug Synthesis Database

【结构式】

【分子编号】54585

【品名】N,N-dimethyl-2-{[(R)-(1-methyl-1H-pyrazol-5-yl)(phenyl)methyl]oxy}-1-ethanamine; N,N-dimethyl-N-(2-{[(R)-(1-methyl-1H-pyrazol-5-yl)(phenyl)methyl]oxy}ethyl)amine

【CA登记号】

【分子式】C₁₅H₂₁N₃O

【分子量】259.35136

【元素组成】C 69.47% H 8.16% N 16.2% O 6.17%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：

The optical resolution of (±)-cizolirtine was accomplished by recrystallizing diastereoisomeric salts formed with the antipodes of di-p-toluoyltartaric acid in isopropanol.

参考文献中间体

合成目标

【1】 Farré, A.J.; Frigola, J.; Cizolirtine Citrate. Drugs Fut 2002, 27, 8, 721.
【2】 Frigola-Constansa, J.; Torrens-Jover, A. (Laboratorios del Dr. Esteve, SA); Resolution of amines. EP 1024137; ES 2130079; US 6187930; WO 9902500 .

中间体编号	品名	分子式	供应商	用于合成
54584	N,N-dimethyl-2-[(1-methyl-1H-pyrazol-5-yl)(phenyl)methoxy]-1-ethanamine; N,N-dimethyl-N-{2-[(1-methyl-1H-pyrazol-5-yl)(phenyl)methoxy]ethyl}amine	C₁₅H₂₁N₃O	详情	详情
54585	N,N-dimethyl-2-{[(R)-(1-methyl-1H-pyrazol-5-yl)(phenyl)methyl]oxy}-1-ethanamine; N,N-dimethyl-N-(2-{[(R)-(1-methyl-1H-pyrazol-5-yl)(phenyl)methyl]oxy}ethyl)amine	C₁₅H₂₁N₃O	详情	详情
54586	N,N-dimethyl-2-{[(S)-(1-methyl-1H-pyrazol-5-yl)(phenyl)methyl]oxy}-1-ethanamine; N,N-dimethyl-N-(2-{[(S)-(1-methyl-1H-pyrazol-5-yl)(phenyl)methyl]oxy}ethyl)amine	C₁₅H₂₁N₃O	详情	详情

Extended Information