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【结 构 式】

【分子编号】54581

【品名】3-iodo-1-propyne

【CA登记号】

【 分 子 式 】C3H3I

【 分 子 量 】165.96129

【元素组成】C 21.71% H 1.82% I 76.47%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

FK-778 is obtained by selective alkylation of leflunomide (I) at the methyl group with propargyl iodide (II) by means of butyl lithium in THF at ­78 C to give N-(4-trifluoromethylphenyl)-5-(3-butynyl)isoxazole-4-carboxamide (III), which is finally treated with water at 0 C.

3 Bartlett, R.R.; Kay, D.P.; Kuo, E.A.; Schleyerbach, R.; Schwab, W. (Aventis Pharma SA); Cyano-2-hydroxy-3-enamide derivs., process for their preparation, their use as drugs, pharmaceutical compsns. containing them and intermediates obtained. EP 0551230; JP 1993310672; US 5308865 .
1 Cullell-Young, M.; Castaner, R.M.; Leeson, P.A.; FK-778. Drugs Fut 2002, 27, 8, 733.
2 Graul, A.; Castaner, J.; Leflunomide < Rec INN >. Drugs Fut 1998, 23, 8, 827.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 54580 5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide C12H9F3N2O2 详情 详情
(II) 54581 3-iodo-1-propyne C3H3I 详情 详情
(III) 54582 5-(3-butynyl)-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide C15H11F3N2O2 详情 详情
Extended Information