【结 构 式】 |
【分子编号】54581 【品名】3-iodo-1-propyne 【CA登记号】 |
【 分 子 式 】C3H3I 【 分 子 量 】165.96129 【元素组成】C 21.71% H 1.82% I 76.47% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)FK-778 is obtained by selective alkylation of leflunomide (I) at the methyl group with propargyl iodide (II) by means of butyl lithium in THF at 78 C to give N-(4-trifluoromethylphenyl)-5-(3-butynyl)isoxazole-4-carboxamide (III), which is finally treated with water at 0 C.
【3】 Bartlett, R.R.; Kay, D.P.; Kuo, E.A.; Schleyerbach, R.; Schwab, W. (Aventis Pharma SA); Cyano-2-hydroxy-3-enamide derivs., process for their preparation, their use as drugs, pharmaceutical compsns. containing them and intermediates obtained. EP 0551230; JP 1993310672; US 5308865 . |
【1】 Cullell-Young, M.; Castaner, R.M.; Leeson, P.A.; FK-778. Drugs Fut 2002, 27, 8, 733. |
【2】 Graul, A.; Castaner, J.; Leflunomide < Rec INN >. Drugs Fut 1998, 23, 8, 827. |
Extended Information