2-methyl-2-propen-1-amine; 2-methyl-2-propenylamine -Drug Synthesis Database

【结构式】

【分子编号】61087

【品名】2-methyl-2-propen-1-amine; 2-methyl-2-propenylamine

【CA登记号】

【分子式】C₄H₉N

【分子量】71.1222

【元素组成】C 67.55% H 12.75% N 19.69%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VIII)

The tosylation of 2-amino-5-chlorobenzophenone (I) with tosyl chloride (II) in pyridine gives 2-tosylamido-5-chlorobenzophenone (III), which is methylated with dimethyl sulfate and sodium methoxide in toluene yielding N-methyl-2-tosylamido-5-chlorobenzophenone (IV). Hydrolysis of (IV) with aqueous sulfuric acid affords 2-methylamino-5-chlorobenzophenone (V), which is acylated with bromoacetyl chloride (VI) in benzene to give N-methyl-2-(bromoacetylamido)-5-chlorobenzophenone (VII). Finally this compound is condensed with 2-methylallylamine (VIII) in acetone

参考文献中间体

合成目标

【1】 Mouzin, G.; Cousse, H.; Stenger, A.; Casadio, S. (Pierre Fabre S.A.); US 4372975 .
【2】 Serradell, M.N.; Castaner, J.; Souto, M.; Dinazafone. Drugs Fut 1984, 9, 7, 501.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10279	(2-Amino-5-chlorophenyl)(phenyl)methanone; 2-Amino-5-chlorobenzophenone	719-59-5	C₁₃H₁₀ClNO	详情	详情
(II)	25151	phenylmethanesulfonyl chloride	1939-99-7	C₇H₇ClO₂S	详情	详情
(III)	61085	N-(2-benzoyl-4-chlorophenyl)(phenyl)methanesulfonamide		C₂₀H₁₆ClNO₃S	详情	详情
(IV)	61086	N-(2-benzoyl-4-chlorophenyl)-N-methylphenylmethanesulfonamide		C₂₁H₁₈ClNO₃S	详情	详情
(V)	33972	[5-chloro-2-(methylamino)phenyl](phenyl)methanone	1022-13-5	C₁₄H₁₂ClNO	详情	详情
(VI)	27903	2-Bromoacetyl chloride	22118-09-8	C₂H₂BrClO	详情	详情
(VII)	33973	N-(2-benzoyl-4-chlorophenyl)-2-bromo-N-methylacetamide		C₁₆H₁₃BrClNO₂	详情	详情
(VIII)	61087	2-methyl-2-propen-1-amine; 2-methyl-2-propenylamine		C₄H₉N	详情	详情

Extended Information