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【结 构 式】

【分子编号】61080

【品名】2,3-dihydro-1-benzothiophene

【CA登记号】

【 分 子 式 】C8H8S

【 分 子 量 】136.21752

【元素组成】C 70.54% H 5.92% S 23.54%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The Friedel-Crafts' condensation of propionyl chloride (I) with 2,3-dihydrobenzo[b]thiophene (II) in dichloroethylene gives 5-propionyl-2,3-dihydrobenzo[b]thiophene (III), which is brominated with Br2 in THF yielding 5-(2-bromopropionyl)-2,3-dihydrobenzo[b]thiophene (IV). Finally this compound is condensed with 4-phenylbutylamine (V) in refluxing methanol and reduced with NaBH4 in the solvent

1 Serradell, M.N.; Castaner, J.; Thorpe, P.J.; Tibalosin. Drugs Fut 1984, 9, 12, 909.
2 Lambellin, G.; Roba, J.; Gillet, C.; Roncocci, R. (Continental Pharma); BE 848496; FR 2370470; FR 2370472; GB 1565080; JP 7797952 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 61080 2,3-dihydro-1-benzothiophene C8H8S 详情 详情
(II) 15967 propanoyl chloride; propionyl chloride 79-03-8 C3H5ClO 详情 详情
(III) 61081 1-(2,3-dihydro-1-benzothiophen-6-yl)-1-propanone C11H12OS 详情 详情
(IV) 61082 2-bromo-1-(2,3-dihydro-1-benzothiophen-6-yl)-1-propanone C11H11BrOS 详情 详情
(V) 37811 4-phenyl-1-butanamine; 4-phenylbutylamine 13214-66-9 C10H15N 详情 详情
Extended Information