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【结 构 式】 
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【分子编号】59213 【品名】 【CA登记号】 |
【 分 子 式 】C25H51Cl2O3PS 【 分 子 量 】533.623302 【元素组成】C 56.27% H 9.63% Cl 13.29% O 8.99% P 5.8% S 6.01% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Treatment of 2-decyloxy-3-(dodecylmercapto)-1-propanol (I) with phosphorus oxychloride in the presence of Et3N gave the intermediate dichlorophosphate ester (II). This was subsequently condensed with 3'-deoxy-3'-azidothymidine (AZT) (III) to produce, after aqueous hydrolysis, the target phosphate diester. The title diester was alternatively obtained by the phospholipase D-catalyzed condensation of AZT (III) with the choline monophosphate ester (IV).
| 【1】 Zilch, H.; Leinert, H.; Mertens, A.; Herrmann, D. (Roche Diagnostics GmbH); New phospholipid derivs. of nucleosides, their preparation and their use as antiviral drugs. DE 4026265; EP 0545966; JP 1994500546; WO 9203462 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 59212 | 2-(decyloxy)-3-(dodecylsulfanyl)-1-propanol | C25H52O2S | 详情 | 详情 | |
| (II) | 59213 | C25H51Cl2O3PS | 详情 | 详情 | ||
| (III) | 25317 | 1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione | 101703-35-9 | C10H13N5O4 | 详情 | 详情 |
| (IV) | 59214 | 9-(decyloxy)-2,2-dimethyl-6-oxo-5,7-dioxa-11-thia-2-azonia-6lambda~5~-phosphatricosan-6-olate | C30H64NO5PS | 详情 | 详情 |
Extended Information