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【结 构 式】 
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【分子编号】59209 【品名】3-ethylphenylcyanamide 【CA登记号】 |
【 分 子 式 】C9H10N2 【 分 子 量 】146.19188 【元素组成】C 73.94% H 6.89% N 19.16% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)(3-Ethylphenyl)cyanamide (III) was prepared by treatment of m-ethylaniline (I) with cyanogen bromide (II) in Et2O. Alkylation of (III) with iodomethane and NaH provided the N-methyl cyanamide (IV). This was finally condensed with 1-naphthylamine hydrochloride (V) by heating at 160 C or in the presence of AlCl3 as the catalyst.
| 【1】 Weber, E.; Keana, J.F.W. (University of Oregon); Tri- and tetra-substd. guanidines and their use as excitatory amino acid antagonists. JP 2002020361; US 5262568; WO 9112797 . |
| 【2】 Durant, G.J.; Nagar, S.S. (CeNeS Pharmaceuticals); Preparation of substd. guanidines. WO 9319042 . |
| 【3】 Reddy, N.L.; et al.; Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: A new, selective noncompetitive NMDA receptor antagonist. J Med Chem 1994, 37, 2, 260. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 59208 | 3-Ethylaniline; m-Ethylaniline | 587-02-0 | C8H11N | 详情 | 详情 |
| (II) | 58017 | (4S)-4-(3-chloropropyl)-2,2-dimethyl-1,3-dioxolane | C8H15ClO2 | 详情 | 详情 | |
| (III) | 59209 | 3-ethylphenylcyanamide | C9H10N2 | 详情 | 详情 | |
| (IV) | 59210 | 3-ethylphenyl(methyl)cyanamide | C10H12N2 | 详情 | 详情 | |
| (V) | 59211 | 1-Aminonaphthalene; 1-Naphthylamine; alpha-Naphthylamine | 134-32-7 | C10H9N | 详情 | 详情 |
Extended Information