【结 构 式】 |
【分子编号】59190 【品名】methyl 5-(acetylamino)-4-oxopentanoate 【CA登记号】 |
【 分 子 式 】C8H13NO4 【 分 子 量 】187.19556 【元素组成】C 51.33% H 7% N 7.48% O 34.19% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(LXVI)Methoxy succinyl cyanide (LXV) was prepared by acylation of cuprous cyanide with methoxy succinyl chloride (XIV). Reduction of the acyl cyanide (XIV) by means of zinc dust in the presence of Ac2O produced the acetylamino ketone (LXVI). Subsequent hydrolysis of (LXVI) in aqueous HCl afforded the target aminoacid.
【1】 Anwar, S.; Pfaltz, A.; Synthesis of alpha-aminoketones via selective reduction of acyl cyanides. Tetrahedron Lett 1984, 25, 28, 2977. |
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