3-[1-(4-fluorophenyl)-5-iodo-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethyl-1-propanamine; N-{3-[1-(4-fluorophenyl)-5-iodo-1,3-dihydro-2-benzofuran-1-yl]propyl}-N,N-dimethylamine -Drug Synthesis Database

【结构式】

【分子编号】56852

【品名】3-[1-(4-fluorophenyl)-5-iodo-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethyl-1-propanamine; N-{3-[1-(4-fluorophenyl)-5-iodo-1,3-dihydro-2-benzofuran-1-yl]propyl}-N,N-dimethylamine

【CA登记号】

【分子式】C₁₉H₂₁FINO

【分子量】425.2847532

【元素组成】C 53.66% H 4.98% F 4.47% I 29.84% N 3.29% O 3.76%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The reaction of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-5-iodo-1,3-dihydroisobenzofuran (I) with CuCN and pyridine in DMF at 140 C gives the target citalopram.

参考文献中间体

合成目标

【1】 Biswas, S.; Kumar, Y.; Sharma, T.K.; Sathyanarayana, S.; Vijayaraghavan, B. (Ranbaxy Laboratories Ltd.); Process for the preparation of citalopram. WO 0272565 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	56852	3-[1-(4-fluorophenyl)-5-iodo-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethyl-1-propanamine; N-{3-[1-(4-fluorophenyl)-5-iodo-1,3-dihydro-2-benzofuran-1-yl]propyl}-N,N-dimethylamine		C₁₉H₂₁FINO	详情	详情

Extended Information