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【结 构 式】

【分子编号】54244

【品名】(3S)-1-benzylpyrrolidinyl ethyl ether; (3S)-1-benzyl-3-ethoxypyrrolidine

【CA登记号】n/a

【 分 子 式 】C13H19NO

【 分 子 量 】205.3

【元素组成】C 76.06% H 9.33% N 6.82% O 7.79%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XIX)

The intermediate 3(S)-ethoxypyrrolidine (XIII) has been obtained by alkylation of 1-benzyl-3(S)-hydroxypyrrolidine (XVIII) with ethyl iodide and NaH in THF to give 1-benzyl-3(S)-ethoxypyrrolidine (XIX), which is finally debenzylated with H2 over Pd/C in methanol.

1 Scherschlicht, R.R.; Widmer, U. (F. Hoffmann-La Roche AG); Tricyclic pyridone deriv.. EP 0496274; JP 1992312585; US 5281711; US 5326769 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XIII) 54241 (3S)-3-ethoxypyrrolidine; ethyl (3S)pyrrolidinyl ether n/a C6H13NO 详情 详情
(XVIII) 54243 (3S)-1-benzyl-3-pyrrolidinol 101385-90-4 C11H15NO 详情 详情
(XIX) 54244 (3S)-1-benzylpyrrolidinyl ethyl ether; (3S)-1-benzyl-3-ethoxypyrrolidine n/a C13H19NO 详情 详情
Extended Information