【结 构 式】 |
【分子编号】54244 【品名】(3S)-1-benzylpyrrolidinyl ethyl ether; (3S)-1-benzyl-3-ethoxypyrrolidine 【CA登记号】n/a |
【 分 子 式 】C13H19NO 【 分 子 量 】205.3 【元素组成】C 76.06% H 9.33% N 6.82% O 7.79% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XIX)The intermediate 3(S)-ethoxypyrrolidine (XIII) has been obtained by alkylation of 1-benzyl-3(S)-hydroxypyrrolidine (XVIII) with ethyl iodide and NaH in THF to give 1-benzyl-3(S)-ethoxypyrrolidine (XIX), which is finally debenzylated with H2 over Pd/C in methanol.
【1】 Scherschlicht, R.R.; Widmer, U. (F. Hoffmann-La Roche AG); Tricyclic pyridone deriv.. EP 0496274; JP 1992312585; US 5281711; US 5326769 . |
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