合成路线1

4-Methylamino-3-nitrobenzoic acid (I) is converted into acid chloride (II) by using SOCl2, and subsequently condensed with ethyl 3-(2-pyridylamino)propionate (III) to produce amide (IV). Reduction of the nitro group of (IV) by catalytic hydrogenation yields the phenylenediamine (V). After acylation of diamine (V) with N-(4-cyanophenyl)glycine (VI), cyclization of the resulting amino amide in refluxing AcOH leads to benzimidazole (VII). The cyano group of (VII) is then transformed into amidine (VIII) employing the Pinner reaction. Finally, acylation of the amidino group of (VIII) with hexyl chloroformate gives rise to the target amidine carbamate derivative