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【结 构 式】 
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【分子编号】59297 【品名】(4aR,7R,7aS)-6-(6-amino-8-sulfanyl-9H-purin-9-yl)-2,7-dihydroxytetrahydro-4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-one 【CA登记号】 |
【 分 子 式 】C10H12N5O6PS 【 分 子 量 】361.275142 【元素组成】C 33.25% H 3.35% N 19.39% O 26.57% P 8.57% S 8.88% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)The title chloro derivative was also obtained by halogen exchange of the previously reported 8-bromoadenosine cyclic phosphate (VI) with CaCl2 in hot DMF. Alternatively, the 8-thioadenosine derivative (VII) was converted into the target compound by treatment with elemental chlorine in methanolic HCl at -15 C.
| 【1】 Muneyama, K.; et al.; Synthesis and biological activity of 8-haloadenosine 3',5'-cyclic phosphates. J Carbohydr Nucleosides Nucleotides 1974, 1, 1, 55. |
| 【2】 Robins, R.K.; Revankar, G.R.; Chang, Y. (Nucleic Acid Res. Inst., Costa Mesa); Treatment of malignant tumours with 8-chloroadenosine 3'-5'-cyclic phosphate, 8-aminoadenosine 3',5'-cyclic phosphate and preparation thereof. EP 0499291; WO 8905648 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 59296 | (4aR,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-2,7-dihydroxytetrahydro-4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-one | C10H11BrN5O6P | 详情 | 详情 | |
| (VII) | 59297 | (4aR,7R,7aS)-6-(6-amino-8-sulfanyl-9H-purin-9-yl)-2,7-dihydroxytetrahydro-4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-one | C10H12N5O6PS | 详情 | 详情 |
Extended Information