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【结 构 式】 
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【分子编号】53949 【品名】methyl 8-anilino-8-oxooctanoate 【CA登记号】 |
【 分 子 式 】C15H21NO3 【 分 子 量 】263.33668 【元素组成】C 68.42% H 8.04% N 5.32% O 18.23% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(XIII)5. The condensation of diacid (XII) with aniline (II) by heating at 190 C gives the monoamide (VII), which is esterified by means of Dowex 50W-X2 in refluxing methanol to yield the monoamide monoester (XIII). Finally, this compound is treated with hydroxylamine and NaOMe in methanol to afford the target hydroxamic acid with overall yields of around 37%.
| 【1】 Stowell, J.C.; et al.; The synthesis of N-hydroxy-N'-phenyloctanediamide and its inhibitory effect on proliferation of AXC rat prostate cancer cells. J Med Chem 1995, 38, 8, 1411. |
合成路线2
该中间体在本合成路线中的序号：(II)
| 【1】 Gediya LK, Chopra P, Purushottamachar P. et al. 2005. A new simple and high-yield synthesis of sub roykuiilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells. J Med Chem, 48 (15): 5047～5051 |
Extended Information