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【结 构 式】 
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【分子编号】53824 【品名】 【CA登记号】n/a |
【 分 子 式 】C33H54O6 【 分 子 量 】546.78816 【元素组成】C 72.49% H 9.95% O 17.56% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(CXLVIII)The tertiary alcohol group of (CXLVII) was dehydrated to (CXLVIII) upon treatment with methanesulfonyl chloride and triethylamine. Diimide reduction of the olefin double bond of (CXLVIII) produced (CXLIX). The acetate ester of (CXLIX) was further hydrolyzed to alcohol (CL) by methanolic KOH. Then, acidic hydrolysis of the ketal protecting groups of (CL) furnished the key precursor (CXXXIX).
| 【1】 Zhou, X.D.; et al.; A new highly stereoselective construction of the sidechain of squalamine through improved Sharpless catalytic asymmetric dihydroxylation. Tetrahedron Lett 2001, 42, 13, 2537. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (CXXXIX) | 53815 | (5S,7R,8R,9S,10S,13R,14S,17R)-7-hydroxy-17-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-10,13-dimethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one | n/a | C27H46O3 | 详情 | 详情 |
| (CXLVII) | 53823 | n/a | C33H56O7 | 详情 | 详情 | |
| (CXLVIII) | 53824 | n/a | C33H54O6 | 详情 | 详情 | |
| (CXLIX) | 53825 | n/a | C33H56O6 | 详情 | 详情 | |
| (CL) | 53826 | n/a | C31H54O5 | 详情 | 详情 |
Extended Information