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【结 构 式】 
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【分子编号】53787 【品名】 【CA登记号】n/a |
【 分 子 式 】C30H52O4Si 【 分 子 量 】504.82598 【元素组成】C 71.38% H 10.38% O 12.68% Si 5.56% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(CIX)In a further synthetic procedure, ketalization of enone (CV) with ethyleneglycol afforded (CVI). After silylation of the primary alcohol group of (CVI) to (CVII), allylic oxidation by means of tert-butyl hydroperoxide and Cr(CO)6 furnished ketone (CVIII). Catalytic hydrogenation of the double bond of (CVIII) to (CIX), followed by ketone reduction with K-Selectride, gave the C-7 alcohol (CX), which was esterified with benzoyl chloride, yielding benzoate ester (CXI). Subsequent desilylation of (CXI) using tetrabutylammonium fluoride provided (CXII).
| 【1】 Kinney, W.A.; Meckler, H.; Zhang, X.; Lee, N.; Jones, S.; Rao, M.N.; Bulliard, M. (Genaera Corp.); Stereoselective synthesis of 24-hydroxylated cpds. useful for the preparation of aminosterols, vitamin D analogs, and other cpds.. WO 9824800 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (CV) | 53783 | (8S,9S,10R,13S,14S,17R)-17-[(1S)-2-hydroxy-1-methylethyl]-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one | n/a | C22H34O2 | 详情 | 详情 |
| (CVI) | 53784 | n/a | C24H38O3 | 详情 | 详情 | |
| (CVII) | 53785 | n/a | C30H52O3Si | 详情 | 详情 | |
| (CVIII) | 53786 | n/a | C30H50O4Si | 详情 | 详情 | |
| (CIX) | 53787 | n/a | C30H52O4Si | 详情 | 详情 | |
| (CX) | 53788 | n/a | C30H54O4Si | 详情 | 详情 | |
| (CXI) | 53789 | n/a | C37H58O5Si | 详情 | 详情 | |
| (CXII) | 53790 | n/a | C31H44O5 | 详情 | 详情 |
Extended Information