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【结 构 式】 
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【分子编号】53713 【品名】(3S,8S,9S,10R,13R,14S,17R)-17-[(1R)-4-hydroxy-1,5-dimethylhexyl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate 【CA登记号】n/a |
【 分 子 式 】C29H48O3 【 分 子 量 】444.69832 【元素组成】C 78.33% H 10.88% O 10.79% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXIX)In an alternative preparation of intermediate (VIII), 3-beta-acetoxy-5-cholenic acid (XXVII) was converted to the corresponding acid chloride, to which was added isopropylcadmium bromide, yielding ketone (XXVIII). Subsequent reduction of (XXVIII) with calcium borohydride in THF, followed by silylation of the resultant alcohol (XXIX), provided intermediate (VIII).
| 【1】 Moriarty, R.M.; et al.; Synthesis of squalamine. A steroidal antibiotic from the shark. Tetrahedron Lett 1994, 35, 44, 8103. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VIII) | 53694 | (3S,8S,9S,10R,13R,14S,17R)-17-((1R)-4-{[tert-butyl(dimethyl)silyl]oxy}-1,5-dimethylhexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | n/a | C35H62O3Si | 详情 | 详情 |
| (XXVII) | 53711 | (4R)-4-[(3S,8S,9S,10R,13R,14S,17R)-3-(acetyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid | n/a | C26H40O4 | 详情 | 详情 |
| (XXVIII) | 53712 | (3S,8S,9S,10R,13R,14S,17R)-17-[(1R)-1,5-dimethyl-4-oxohexyl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | n/a | C29H46O3 | 详情 | 详情 |
| (XXIX) | 53713 | (3S,8S,9S,10R,13R,14S,17R)-17-[(1R)-4-hydroxy-1,5-dimethylhexyl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | n/a | C29H48O3 | 详情 | 详情 |
Extended Information