4-{[(2S)-1-({[(1R)-1-(1,3-benzodioxol-5-yl)butyl]amino}carbonyl)-3,3-diethyl-4-oxoazetidinyl]oxy}benzoyl chloride -Drug Synthesis Database

【结构式】

【分子编号】53620

【品名】4-{[(2S)-1-({[(1R)-1-(1,3-benzodioxol-5-yl)butyl]amino}carbonyl)-3,3-diethyl-4-oxoazetidinyl]oxy}benzoyl chloride

【CA登记号】n/a

【分子式】C₂₆H₂₉ClN₂O₆

【分子量】500.97884

【元素组成】C 62.34% H 5.83% Cl 7.08% N 5.59% O 19.16%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The title compound has been prepared by treatment of carboxylic acid (I) with oxalyl chloride, followed by condensation of the resulting acid chloride (II) with N-methylpiperazine (III).

参考文献中间体

合成目标

【1】 Doherty, J.B.; Finke, P.E.; Dorn, C.P.; Maccoss, M.; Durette, P.L.; Mills, S.G.; Shah, S.K.; Lanza, T.J.; Sahoo, S.P.; Hagmann, W.K.; Hale, J.J. (Merck & Co., Inc.); New substd. azetidinones as antiinflammatory and antidegenerative agents. EP 0595557; JP 1994263723; US 5591737; US 5747485; WO 9410142 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	53619	4-{[(2S)-1-({[(1R)-1-(1,3-benzodioxol-5-yl)butyl]amino}carbonyl)-3,3-diethyl-4-oxoazetidinyl]oxy}benzoic acid	n/a	C₂₆H₃₀N₂O₇	详情	详情
(II)	53620	4-{[(2S)-1-({[(1R)-1-(1,3-benzodioxol-5-yl)butyl]amino}carbonyl)-3,3-diethyl-4-oxoazetidinyl]oxy}benzoyl chloride	n/a	C₂₆H₂₉ClN₂O₆	详情	详情
(III)	10061	1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine	109-01-3	C₅H₁₂N₂	详情	详情

Extended Information