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【结 构 式】

【分子编号】53620

【品名】4-{[(2S)-1-({[(1R)-1-(1,3-benzodioxol-5-yl)butyl]amino}carbonyl)-3,3-diethyl-4-oxoazetidinyl]oxy}benzoyl chloride

【CA登记号】n/a

【 分 子 式 】C26H29ClN2O6

【 分 子 量 】500.97884

【元素组成】C 62.34% H 5.83% Cl 7.08% N 5.59% O 19.16%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

The title compound has been prepared by treatment of carboxylic acid (I) with oxalyl chloride, followed by condensation of the resulting acid chloride (II) with N-methylpiperazine (III).

1 Doherty, J.B.; Finke, P.E.; Dorn, C.P.; Maccoss, M.; Durette, P.L.; Mills, S.G.; Shah, S.K.; Lanza, T.J.; Sahoo, S.P.; Hagmann, W.K.; Hale, J.J. (Merck & Co., Inc.); New substd. azetidinones as antiinflammatory and antidegenerative agents. EP 0595557; JP 1994263723; US 5591737; US 5747485; WO 9410142 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 53619 4-{[(2S)-1-({[(1R)-1-(1,3-benzodioxol-5-yl)butyl]amino}carbonyl)-3,3-diethyl-4-oxoazetidinyl]oxy}benzoic acid n/a C26H30N2O7 详情 详情
(II) 53620 4-{[(2S)-1-({[(1R)-1-(1,3-benzodioxol-5-yl)butyl]amino}carbonyl)-3,3-diethyl-4-oxoazetidinyl]oxy}benzoyl chloride n/a C26H29ClN2O6 详情 详情
(III) 10061 1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine 109-01-3 C5H12N2 详情 详情
Extended Information