(Z)-3-anilino-3-{[2-oxo-2-(3-pyridinyl)ethyl]sulfanyl}-2-propenenitrile -Drug Synthesis Database

【结构式】

【分子编号】53539

【品名】(Z)-3-anilino-3-{[2-oxo-2-(3-pyridinyl)ethyl]sulfanyl}-2-propenenitrile

【CA登记号】n/a

【分子式】C₁₆H₁₃N₃OS

【分子量】295.36484

【元素组成】C 65.06% H 4.44% N 14.23% O 5.42% S 10.86%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

The reaction of aniline (I) with di(2-pyridyl)thione (DPT) gives the corresponding isothiocyanate (II), which is condensed with cyanamide (III) and 2-bromo-1-(3-pyridyl)ethanone (IV) by means of NaOMe to yield the adduct (V). This compound, without isolation, cyclizes to the target thiazole.

参考文献中间体

合成目标

【1】 Sorensen, A.R.; Engelhardt, S.; Kurtzhals, P.; Urso, B.; Bowler, A.N.; 2,4-Diaminothiazoles: A novel class of glycogen synthase kinase-3 (GSK-3) inhibitors. 11th RSC-SCI Med Chem Symp (Sept 9 2001, Cambridge) 2001, Abst P20.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12294	Aniline; Phenylamine	62-53-3	C₆H₇N	详情	详情
(II)	22146	1-isothiocyanatobenzene; phenyl isothiocyanate	103-72-0	C₇H₅NS	详情	详情
(III)	19648	Cyanamide	420-04-2	CH₂N₂	详情	详情
(IV)	53085	2-bromo-1-(3-pyridinyl)-1-ethanone	n/a	C₇H₆BrNO	详情	详情
(V)	53539	(Z)-3-anilino-3-{[2-oxo-2-(3-pyridinyl)ethyl]sulfanyl}-2-propenenitrile	n/a	C₁₆H₁₃N₃OS	详情	详情

Extended Information