【结 构 式】 |
【分子编号】53538 【品名】N-((Z)-anilino{[2-oxo-2-(3-pyridinyl)ethyl]sulfanyl}methylidene)guanidine 【CA登记号】n/a |
【 分 子 式 】C15H15N5OS 【 分 子 量 】313.3832 【元素组成】C 57.49% H 4.82% N 22.35% O 5.11% S 10.23% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)The reaction of N1-amidino-N3-phenylthiourea (I) with 2-bromo-1-(3-pyridyl)ethanone (II) in ethanol/acetone gives the N1-amidino-S-[2-oxo-2-(3-pyridyl)ethyl]-N3-phenylisothiourea (III), which without isolation is cyclized to the target aminothiazole by means of TEA.
【1】 Sorensen, A.R.; Engelhardt, S.; Kurtzhals, P.; Urso, B.; Bowler, A.N.; 2,4-Diaminothiazoles: A novel class of glycogen synthase kinase-3 (GSK-3) inhibitors. 11th RSC-SCI Med Chem Symp (Sept 9 2001, Cambridge) 2001, Abst P20. |
【2】 Olesen, P.H.; Kurtzhals, P.; Bowler, A.N.; Soerensen, A.R.; Worsaae, H.; Hansen, B.F. (Novo Nordisk A/S); 2,4-Diaminothiazole derivs.. WO 0156567 . |
Extended Information