N-[(Z)-{[2-oxo-2-(3-pyridinyl)ethyl]sulfanyl}(propylamino)methylidene]guanidine -Drug Synthesis Database

【结构式】

【分子编号】53535

【品名】N-[(Z)-{[2-oxo-2-(3-pyridinyl)ethyl]sulfanyl}(propylamino)methylidene]guanidine

【CA登记号】n/a

【分子式】C₁₂H₁₇N₅OS

【分子量】279.36608

【元素组成】C 51.59% H 6.13% N 25.07% O 5.73% S 11.48%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reaction of N1-amidino-N3-propylthiourea (I) with 2-bromo-1-(3-pyridyl)ethanone (II) in ethanol/acetone gives the N1-amidino-S-[2-oxo-2-(3-pyridyl)ethyl]-N3-propylisothiourea (III), which without isolation is cyclized to the target aminothiazole by means of TEA.

参考文献中间体

合成目标

【1】 Sorensen, A.R.; Engelhardt, S.; Kurtzhals, P.; Urso, B.; Bowler, A.N.; 2,4-Diaminothiazoles: A novel class of glycogen synthase kinase-3 (GSK-3) inhibitors. 11th RSC-SCI Med Chem Symp (Sept 9 2001, Cambridge) 2001, Abst P20.
【2】 Olesen, P.H.; Kurtzhals, P.; Bowler, A.N.; Soerensen, A.R.; Worsaae, H.; Hansen, B.F. (Novo Nordisk A/S); 2,4-Diaminothiazole derivs.. WO 0156567 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	53534	1-Amidino-3-propyl-2-thiourea	n/a	C₅H₁₂N₄S	详情	详情
(II)	53058	(2-benzyl-4,8,8-trimethyl-6,10-dioxa-2-azaspiro[4.5]dec-4-yl)methyl azide; 4-(azidomethyl)-2-benzyl-4,8,8-trimethyl-6,10-dioxa-2-azaspiro[4.5]decane	n/a	C₁₈H₂₆N₄O₂	详情	详情
(III)	53535	N-[(Z)-{[2-oxo-2-(3-pyridinyl)ethyl]sulfanyl}(propylamino)methylidene]guanidine	n/a	C₁₂H₁₇N₅OS	详情	详情

Extended Information