1-(3-acetyl-5-aminophenyl)-1-ethanone -Drug Synthesis Database

【结构式】

【分子编号】53487

【品名】1-(3-acetyl-5-aminophenyl)-1-ethanone

【CA登记号】n/a

【分子式】C₁₀H₁₁NO₂

【分子量】177.20288

【元素组成】C 67.78% H 6.26% N 7.9% O 18.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The reaction of decanedioyl dichloride (I) with 3,5-diacetylaniline (II) by means of pyridine in dichloromethane gives the corresponding diamide (III), which is condensed with aminoguanidine (IV) in refluxing aqueous ethanol to afford the target tetrakis amidinohydrazone.

参考文献中间体

合成目标

【1】 Cerami, A.; Ulrich, P.; Tracey, K.J.; Bianchi, M. (Picower Institute for Medical Research); Guanylhydrazones for treating inflammatory conditions. EP 0746312; EP 1160240; US 5599984; WO 9519767 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	53486	Sebacic acid chloride; Sebacoyl chloride; Sebacoyl dichloride; Sebacic acid dichloride	111-19-3	C₁₀H₁₆Cl₂O₂	详情	详情
(II)	53487	1-(3-acetyl-5-aminophenyl)-1-ethanone	n/a	C₁₀H₁₁NO₂	详情	详情
(III)	53488	N1,N10-bis(3,5-diacetylphenyl)decanediamide	n/a	C₃₀H₃₆N₂O₆	详情	详情
(IV)	10015	1-Hydrazinecarboximidamide; Hydrazinecarboximidamide	79-17-4	CH₆N₄	详情	详情

Extended Information