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【结 构 式】 
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【分子编号】53360 【品名】N-[(10S,11R,12R,15S,18S)-15-(2-amino-2-oxoethyl)-9,14,17-trioxo-10,11,23-tris[(triethylsilyl)oxy]-12-{[(triethylsilyl)oxy]methyl}-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaen-18-yl]-3-methyl-2-oxopentanamide 【CA登记号】n/a |
【 分 子 式 】C54H91N5O10Si4 【 分 子 量 】1082.68624 【元素组成】C 59.91% H 8.47% N 6.47% O 14.78% Si 10.38% |
合成路线1
该中间体在本合成路线中的序号：(XXV)The selective protection of the primary OH group of (XVII) with Tips-Cl and imidazole yields the silyl ether (XVIII), which is treated with TFA in dichloromethane to afford the carboxylic acid (XIX). The macrolactamization of (XIX) by means of EDC, HOAt and DIEA in DMF/dichloromethane provides the macrolactam (XX), which is debenzylated by hydrogenation with H2 over Pd/C in ethanol to furnish the aminophenol (XXI). The condensation of (XXI) with racemic 3-methyl-2-oxopentanoic acid (XXII) by means of EDC and HOAt in DMF/dichloromethane gives the amide (XXIII) as a diastereomeric mixture. The desilylation of (XXIII) by means of HF and pyridine gives the tetrahydroxy compound (XXIV), which is fully resilylated with Tes-OTf and lutidine in dichloromethane to yield the tetra-silyl ether (XXV).
| 【1】 Lin, S.N.; Danishefsky, S.J.; The total synthesis of proteasome inhibitors TMC-95A and TMC-95B: Discovery of a new method to generate cis-propenyl amides. Angew Chem. Int Ed 2002, 41, 3, 512. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVII) | 53353 | tert-butyl (2S)-4-amino-2-[((2S)-3-[4-(benzyloxy)-3-((3S)-3-{(1R,2R)-2-[(tert-butoxycarbonyl)amino]-1,3-dihydroxypropyl}-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-7-yl)phenyl]-2-{[(benzyloxy)carbonyl]amino}propanoyl)amino]-4-oxobutanoate | n/a | C48H57N5O13 | 详情 | 详情 |
| (XVIII) | 53354 | tert-butyl (2S)-4-amino-2-[((2S)-3-[4-(benzyloxy)-3-((3S)-3-{(1R,2R)-2-[(tert-butoxycarbonyl)amino]-1-hydroxy-3-[(triisopropylsilyl)oxy]propyl}-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-7-yl)phenyl]-2-{[(benzyloxy)carbonyl]amino}propanoyl)amino]-4-oxobutanoate | n/a | C57H77N5O13Si | 详情 | 详情 |
| (XIX) | 53355 | (2S)-4-amino-2-[((2S)-3-[4-(benzyloxy)-3-((3S)-3-{(1R,2R)-2-[(tert-butoxycarbonyl)amino]-1-hydroxy-3-[(triisopropylsilyl)oxy]propyl}-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-7-yl)phenyl]-2-{[(benzyloxy)carbonyl]amino}propanoyl)amino]-4-oxobutanoic acid | n/a | C53H69N5O13Si | 详情 | 详情 |
| (XX) | 53356 | benzyl (10S,11R,12R,15S,18S)-15-(2-amino-2-oxoethyl)-23-(benzyloxy)-10,11-dihydroxy-9,14,17-trioxo-12-{[(triisopropylsilyl)oxy]methyl}-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaen-18-ylcarbamate | n/a | C48H59N5O10Si | 详情 | 详情 |
| (XXI) | 53357 | 2-[(10S,11R,12R,15S,18S)-18-amino-10,11,23-trihydroxy-9,14,17-trioxo-12-{[(triisopropylsilyl)oxy]methyl}-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaen-15-yl]acetamide | n/a | C33H47N5O8Si | 详情 | 详情 |
| (XXII) | 46950 | 3-methyl-2-oxopentanoic acid | C6H10O3 | 详情 | 详情 | |
| (XXIII) | 53358 | N-[(10S,11R,12R,15S,18S)-15-(2-amino-2-oxoethyl)-10,11,23-trihydroxy-9,14,17-trioxo-12-{[(triisopropylsilyl)oxy]methyl}-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaen-18-yl]-3-methyl-2-oxopentanamide | n/a | C39H55N5O10Si | 详情 | 详情 |
| (XXIV) | 53359 | N-[(10S,11R,12R,15S,18S)-15-(2-amino-2-oxoethyl)-10,11,23-trihydroxy-12-(hydroxymethyl)-9,14,17-trioxo-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaen-18-yl]-3-methyl-2-oxopentanamide | n/a | C30H35N5O10 | 详情 | 详情 |
| (XXV) | 53360 | N-[(10S,11R,12R,15S,18S)-15-(2-amino-2-oxoethyl)-9,14,17-trioxo-10,11,23-tris[(triethylsilyl)oxy]-12-{[(triethylsilyl)oxy]methyl}-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaen-18-yl]-3-methyl-2-oxopentanamide | n/a | C54H91N5O10Si4 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(XXV)The oxidation of the primary silyl ether of (XXV) with the Jones reagent gives a mixture of the carboxylic acid derivatives (XXVI) and (XXVII), which is condensed with the silylated amine (XVIII) by means of EDC and HOAT in DMF/dichloromethane to yield a mixture of the corresponding amides (XXIX) and (XXX). The rearrangement of the mixture (XXIX) + (XXX) in refluxing o-xylene affords provided a mixture of the (E)-propenylamides (XXXI) and (XXXII), which is desilylated by means of HF and pyridine in THF to give compound (XXXIII) as a diastereomeric mixture that is separated by RP-HPLC to afford the target TMC-95A.
| 【1】 Lin, S.N.; Danishefsky, S.J.; The total synthesis of proteasome inhibitors TMC-95A and TMC-95B: Discovery of a new method to generate cis-propenyl amides. Angew Chem. Int Ed 2002, 41, 3, 512. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XXV) | 53360 | N-[(10S,11R,12R,15S,18S)-15-(2-amino-2-oxoethyl)-9,14,17-trioxo-10,11,23-tris[(triethylsilyl)oxy]-12-{[(triethylsilyl)oxy]methyl}-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaen-18-yl]-3-methyl-2-oxopentanamide | n/a | C54H91N5O10Si4 | 详情 | 详情 |
| (XXVI) | 53361 | (10S,11R,12S,15S,18S)-15-(2-amino-2-oxoethyl)-23-hydroxy-18-[(3-methyl-2-oxopentanoyl)amino]-9,14,17-trioxo-10,11-bis[(triethylsilyl)oxy]-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaene-12-carboxylic acid | n/a | C42H61N5O11Si2 | 详情 | 详情 |
| (XXVII) | 53362 | (10S,11R,12S,15S,18S)-15-(2-amino-2-oxoethyl)-18-[(3-methyl-2-oxopentanoyl)amino]-9,14,17-trioxo-10,11,23-tris[(triethylsilyl)oxy]-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaene-12-carboxylic acid | n/a | C48H75N5O11Si3 | 详情 | 详情 |
| (XXVIII) | 53368 | 1-(triethylsilyl)-2-propen-1-amine; 1-(triethylsilyl)-2-propenylamine | n/a | C9H21NSi | 详情 | 详情 |
| (XXIX) | 53363 | (10S,11R,12S,15S,18S)-15-(2-amino-2-oxoethyl)-23-hydroxy-18-[(3-methyl-2-oxopentanoyl)amino]-9,14,17-trioxo-10,11-bis[(triethylsilyl)oxy]-N-[1-(triethylsilyl)-2-propenyl]-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaene-12-carboxylic acid | n/a | C51H80N6O10Si3 | 详情 | 详情 |
| (XXX) | 53364 | (10S,11R,12S,15S,18S)-15-(2-amino-2-oxoethyl)-18-[(3-methyl-2-oxopentanoyl)amino]-9,14,17-trioxo-10,11,23-tris[(triethylsilyl)oxy]-N-[1-(triethylsilyl)-2-propenyl]-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaene-12-carboxylic acid | n/a | C57H94N6O10Si4 | 详情 | 详情 |
| (XXXI) | 53365 | (10S,11R,12S,15S,18S)-15-(2-amino-2-oxoethyl)-23-hydroxy-18-[(3-methyl-2-oxopentanoyl)amino]-9,14,17-trioxo-N-[(Z)-1-propenyl]-10,11-bis[(triethylsilyl)oxy]-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaene-12-carboxilic acid | n/a | C45H66N6O10Si2 | 详情 | 详情 |
| (XXXII) | 53366 | (10S,11R,12S,15S,18S)-15-(2-amino-2-oxoethyl)-18-[(3-methyl-2-oxopentanoyl)amino]-9,14,17-trioxo-N-[(Z)-1-propenyl]-10,11,23-tris[(triethylsilyl)oxy]-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaene-12-carboxamide | n/a | C51H80N6O10Si3 | 详情 | 详情 |
| (XXXIII) | 53367 | (10S,11R,12S,15S,18S)-15-(2-amino-2-oxoethyl)-10,11,23-trihydroxy-18-[(3-methyl-2-oxopentanoyl)amino]-9,14,17-trioxo-N-[(Z)-1-propenyl]-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaene-12-carboxamide | n/a | C33H38N6O10 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(XXI)The reaction of (XV) with TFA promotes the cleavage of the oxazolidine ring and the Boc and Mom protecting groups yielding the amino tetrahydroxy derivative (XVI), which is condensed with 3-methyl-2-oxopentanoic acid (XVII) by means of HOAt and EDC in THF to afford the corresponding amide (XVIII). The hydrogenolysis of (XVIII) with H2 over Pd/C in ethanol promotes the cleavage of the benzyloxy and benzyloxycarbonyl groups which provides the requisite aminoacid (XIX), suitable for macrocyclization. This is performed by means of EDC and HOAt in DMF/dichloromethane to provide the macrocyclic compound (XX). Finally, this compound is treated with Tes-OTf and lutidine in DMF/dichloromethane to obtain the fully silylated, already reported, macrocyclic intermediate (XXI). (see Scheme nos. 27460201c and 27460201d, intermediate (XXV).
| 【1】 Albrecht, B.K.; Williams, R.M.; A concise formal total synthesis of TMC-95A/B proteasome inhibitors. Org Lett 2003, 5, 2, 197. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| /XVI) | 61826 | benzyl (2S)-4-amino-2-[((2S)-2-amino-3-{3-[(3S)-3-((1R,2R)-2-{[(benzyloxy)carbonyl]amino}-1,3-dihydroxypropyl)-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-7-yl]-4-hydroxyphenyl}propanoyl)amino]-4-oxobutanoate | C39H41N5O11 | 详情 | 详情 | |
| (XV) | 61823 | benzyl (4R)-4-[(R)-{(3S)-7-[5-{(2S)-3-({(1S)-3-amino-1-[(benzyloxy)carbonyl]-3-oxopropyl}amino)-2-[(tert-butoxycarbonyl)amino]-3-oxopropyl}-2-(methoxymethoxy)phenyl]-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl}(hydroxy)methyl]-2,2-dimethyl-1,3-oxazoli | C49H57N5O14 | 详情 | 详情 | |
| (XVIII) | 61827 | benzyl (2S)-4-amino-2-({(2S)-3-{3-[(3S)-3-((1R,2R)-2-{[(benzyloxy)carbonyl]amino}-1,3-dihydroxypropyl)-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-7-yl]-4-hydroxyphenyl}-2-[(3-methyl-2-oxopentanoyl)amino]propanoyl}amino)-4-oxobutanoate | C45H49N5O13 | 详情 | 详情 | |
| (XIX) | 61828 | (2S)-4-amino-2-({(2S)-3-(3-{(3S)-3-[(1R,2R)-2-amino-1,3-dihydroxypropyl]-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-7-yl}-4-hydroxyphenyl)-2-[(3-methyl-2-oxopentanoyl)amino]propanoyl}amino)-4-oxobutanoic acid | C30H37N5O11 | 详情 | 详情 | |
| (XX) | 53359 | N-[(10S,11R,12R,15S,18S)-15-(2-amino-2-oxoethyl)-10,11,23-trihydroxy-12-(hydroxymethyl)-9,14,17-trioxo-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaen-18-yl]-3-methyl-2-oxopentanamide | n/a | C30H35N5O10 | 详情 | 详情 |
| (XXI) | 53360 | N-[(10S,11R,12R,15S,18S)-15-(2-amino-2-oxoethyl)-9,14,17-trioxo-10,11,23-tris[(triethylsilyl)oxy]-12-{[(triethylsilyl)oxy]methyl}-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaen-18-yl]-3-methyl-2-oxopentanamide | n/a | C54H91N5O10Si4 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(XXV)The selective protection of the primary OH group of (XVII) with Tips-Cl and imidazole yields the silyl ether (XVIII), which is treated with TFA in dichloromethane to afford the carboxylic acid (XIX). The macrolactamization of (XIX) by means of EDC, HOAt and DIEA in DMF/dichloromethane provides the macrolactam (XX), which is debenzylated by hydrogenation with H2 over Pd/C in ethanol to furnish the aminophenol (XXI). The condensation of (XXI) with racemic 3-methyl-2-oxopentanoic acid (XXII) by means of EDC and HOAt in DMF/dichloromethane gives the amide (XXIII) as a diastereomeric mixture. The desilylation of (XXIII) by means of HF and pyridine gives the tetrahydroxy compound (XXIV), which is fully resilylated with Tes-OTf and lutidine in dichloromethane to yield the tetra-silyl ether (XXV).
| 【1】 Lin, S.N.; Danishefsky, S.J.; The total synthesis of proteasome inhibitors TMC-95A and TMC-95B: Discovery of a new method to generate cis-propenyl amides. Angew Chem. Int Ed 2002, 41, 3, 512. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVII) | 53353 | tert-butyl (2S)-4-amino-2-[((2S)-3-[4-(benzyloxy)-3-((3S)-3-{(1R,2R)-2-[(tert-butoxycarbonyl)amino]-1,3-dihydroxypropyl}-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-7-yl)phenyl]-2-{[(benzyloxy)carbonyl]amino}propanoyl)amino]-4-oxobutanoate | n/a | C48H57N5O13 | 详情 | 详情 |
| (XVIII) | 53354 | tert-butyl (2S)-4-amino-2-[((2S)-3-[4-(benzyloxy)-3-((3S)-3-{(1R,2R)-2-[(tert-butoxycarbonyl)amino]-1-hydroxy-3-[(triisopropylsilyl)oxy]propyl}-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-7-yl)phenyl]-2-{[(benzyloxy)carbonyl]amino}propanoyl)amino]-4-oxobutanoate | n/a | C57H77N5O13Si | 详情 | 详情 |
| (XIX) | 53355 | (2S)-4-amino-2-[((2S)-3-[4-(benzyloxy)-3-((3S)-3-{(1R,2R)-2-[(tert-butoxycarbonyl)amino]-1-hydroxy-3-[(triisopropylsilyl)oxy]propyl}-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-7-yl)phenyl]-2-{[(benzyloxy)carbonyl]amino}propanoyl)amino]-4-oxobutanoic acid | n/a | C53H69N5O13Si | 详情 | 详情 |
| (XX) | 53356 | benzyl (10S,11R,12R,15S,18S)-15-(2-amino-2-oxoethyl)-23-(benzyloxy)-10,11-dihydroxy-9,14,17-trioxo-12-{[(triisopropylsilyl)oxy]methyl}-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaen-18-ylcarbamate | n/a | C48H59N5O10Si | 详情 | 详情 |
| (XXI) | 53357 | 2-[(10S,11R,12R,15S,18S)-18-amino-10,11,23-trihydroxy-9,14,17-trioxo-12-{[(triisopropylsilyl)oxy]methyl}-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaen-15-yl]acetamide | n/a | C33H47N5O8Si | 详情 | 详情 |
| (XXII) | 46950 | 3-methyl-2-oxopentanoic acid | C6H10O3 | 详情 | 详情 | |
| (XXIII) | 53358 | N-[(10S,11R,12R,15S,18S)-15-(2-amino-2-oxoethyl)-10,11,23-trihydroxy-9,14,17-trioxo-12-{[(triisopropylsilyl)oxy]methyl}-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaen-18-yl]-3-methyl-2-oxopentanamide | n/a | C39H55N5O10Si | 详情 | 详情 |
| (XXIV) | 53359 | N-[(10S,11R,12R,15S,18S)-15-(2-amino-2-oxoethyl)-10,11,23-trihydroxy-12-(hydroxymethyl)-9,14,17-trioxo-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaen-18-yl]-3-methyl-2-oxopentanamide | n/a | C30H35N5O10 | 详情 | 详情 |
| (XXV) | 53360 | N-[(10S,11R,12R,15S,18S)-15-(2-amino-2-oxoethyl)-9,14,17-trioxo-10,11,23-tris[(triethylsilyl)oxy]-12-{[(triethylsilyl)oxy]methyl}-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaen-18-yl]-3-methyl-2-oxopentanamide | n/a | C54H91N5O10Si4 | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(XXV)The oxidation of the primary silyl ether of (XXV) with the Jones reagent gives a mixture of the carboxylic acid derivatives (XXVI) and (XXVII). This mixture is condensed with the silylated amine (XXVIII) by means of EDC and HOAt in DMF/dichloromethane to yield a mixture of the corresponding amides (XXIX) and (XXX). The rearrangement of the mixture (XXIX) + (XXX) in refluxing o-xylene affords provided a mixture of the (E)-propenylamides (XXXI) and (XXXII), which is desilylated by means of HF and pyridine in THF to give compound (XXXIII) as a diastereomeric mixture that is separated by RP-HPLC to afford the target TMC-95B.
| 【1】 Lin, S.N.; Danishefsky, S.J.; The total synthesis of proteasome inhibitors TMC-95A and TMC-95B: Discovery of a new method to generate cis-propenyl amides. Angew Chem. Int Ed 2002, 41, 3, 512. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XXV) | 53360 | N-[(10S,11R,12R,15S,18S)-15-(2-amino-2-oxoethyl)-9,14,17-trioxo-10,11,23-tris[(triethylsilyl)oxy]-12-{[(triethylsilyl)oxy]methyl}-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaen-18-yl]-3-methyl-2-oxopentanamide | n/a | C54H91N5O10Si4 | 详情 | 详情 |
| (XXVI) | 53361 | (10S,11R,12S,15S,18S)-15-(2-amino-2-oxoethyl)-23-hydroxy-18-[(3-methyl-2-oxopentanoyl)amino]-9,14,17-trioxo-10,11-bis[(triethylsilyl)oxy]-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaene-12-carboxylic acid | n/a | C42H61N5O11Si2 | 详情 | 详情 |
| (XXVII) | 53362 | (10S,11R,12S,15S,18S)-15-(2-amino-2-oxoethyl)-18-[(3-methyl-2-oxopentanoyl)amino]-9,14,17-trioxo-10,11,23-tris[(triethylsilyl)oxy]-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaene-12-carboxylic acid | n/a | C48H75N5O11Si3 | 详情 | 详情 |
| (XXVIII) | 53368 | 1-(triethylsilyl)-2-propen-1-amine; 1-(triethylsilyl)-2-propenylamine | n/a | C9H21NSi | 详情 | 详情 |
| (XXIX) | 53363 | (10S,11R,12S,15S,18S)-15-(2-amino-2-oxoethyl)-23-hydroxy-18-[(3-methyl-2-oxopentanoyl)amino]-9,14,17-trioxo-10,11-bis[(triethylsilyl)oxy]-N-[1-(triethylsilyl)-2-propenyl]-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaene-12-carboxylic acid | n/a | C51H80N6O10Si3 | 详情 | 详情 |
| (XXX) | 53364 | (10S,11R,12S,15S,18S)-15-(2-amino-2-oxoethyl)-18-[(3-methyl-2-oxopentanoyl)amino]-9,14,17-trioxo-10,11,23-tris[(triethylsilyl)oxy]-N-[1-(triethylsilyl)-2-propenyl]-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaene-12-carboxylic acid | n/a | C57H94N6O10Si4 | 详情 | 详情 |
| (XXXI) | 53365 | (10S,11R,12S,15S,18S)-15-(2-amino-2-oxoethyl)-23-hydroxy-18-[(3-methyl-2-oxopentanoyl)amino]-9,14,17-trioxo-N-[(Z)-1-propenyl]-10,11-bis[(triethylsilyl)oxy]-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaene-12-carboxilic acid | n/a | C45H66N6O10Si2 | 详情 | 详情 |
| (XXXII) | 53366 | (10S,11R,12S,15S,18S)-15-(2-amino-2-oxoethyl)-18-[(3-methyl-2-oxopentanoyl)amino]-9,14,17-trioxo-N-[(Z)-1-propenyl]-10,11,23-tris[(triethylsilyl)oxy]-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaene-12-carboxamide | n/a | C51H80N6O10Si3 | 详情 | 详情 |
| (XXXIII) | 53367 | (10S,11R,12S,15S,18S)-15-(2-amino-2-oxoethyl)-10,11,23-trihydroxy-18-[(3-methyl-2-oxopentanoyl)amino]-9,14,17-trioxo-N-[(Z)-1-propenyl]-8,13,16-triazatetracyclo[18.3.1.0~2,7~.0~6,10~]tetracosa-1(24),2,4,6,20,22-hexaene-12-carboxamide | n/a | C33H38N6O10 | 详情 | 详情 |