2-cyclohexylidene-1-hydrazinecarboxamide -Drug Synthesis Database

【结构式】

【分子编号】63587

【品名】2-cyclohexylidene-1-hydrazinecarboxamide

【CA登记号】

【分子式】C₇H₁₃N₃O

【分子量】155.19984

【元素组成】C 54.17% H 8.44% N 27.07% O 10.31%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

In an alternative method, condensation of semicarbazide hydrochloride (I) with cyclohexanone (II) yields the semicarbazone (III). Subsequent reaction of (III) with ethyl chloroacetate (IV) in the presence of NaOMe gives rise to the cyclohexylidene aminohydantoin (V). Treatment of (V) with 5-(p-nitrophenyl)furfural (VI) under acidic conditions affords the furfurylidene aminohydantoin (VII). This is finally converted into the corresponding sodium salt employing methanolic NaOMe (3).

参考文献中间体

合成目标

【1】 Martin-Escudero Perez, U.; Izquierdo Sanjose, M.; Process for obtaining 1-[(5-(p-nitrophenyl)furfuryliden)amino]hydantoin and its sodium salt. ES 458000 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	23944	1-Hydrazinecarboxamide	563-41-7	CH₅N₃O	详情	详情
(II)	11059	Cyclohexanone	108-94-1	C₆H₁₀O	详情	详情
(III)	63587	2-cyclohexylidene-1-hydrazinecarboxamide		C₇H₁₃N₃O	详情	详情
(IV)	16601	ethyl chloroacetate; ethyl 2-chloroacetate	105-39-5	C₄H₇ClO₂	详情	详情
(V)	63588	1-(cyclohexylideneamino)-2,4-imidazolidinedione		C₉H₁₃N₃O₂	详情	详情
(VI)	63583	5-(4-nitrophenyl)-2-furaldehyde		C₁₁H₇NO₄	详情	详情
(VII)	63586	1-({(E)-[5-(4-nitrophenyl)-2-furyl]methylidene}amino)-2,4-imidazolidinedione		C₁₄H₁₀N₄O₅	详情	详情

Extended Information