合成路线1

The reaction of 2-(tert-butoxycarbonylamino)hexadecanoic acid (I) with ethyl chloroformate (II) and NMM in THF gives the mixed anhydride (III), which is reduced by means of NaBH4 in methanol to yield the corresponding hexadecanol (IV). The reaction of (IV) with MsCl and TEA affords the mesylate (V), which is treated with sodium azide in DMF to provide the azido derivative (VI). The reduction of (VI) with H2 over Pd/C in chloroform gives the corresponding amine (VII), which is finally alkylated with ethyl bromide and TEA in DMF to yield the target tertiary amine.