【结 构 式】 |
【分子编号】63160 【品名】(Z)-2-cyclopropyl-3-hydroxy-2-propenenitrile 【CA登记号】 |
【 分 子 式 】C6H7NO 【 分 子 量 】109.12772 【元素组成】C 66.04% H 6.47% N 12.84% O 14.66% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)The reaction of 2-cyclopropylacetonitrile (I) with ethyl formate (II) by means of t-BuOK in THF gives the hydroxymethylene derivative (III), which is cyclized with 1-(2-fluorobenzyl)pyrazolo[3,4-b]pyridine-3-carboxamidine (IV)(see scheme no. 28591301a, intermediate (IX)) by heating at 105 C to afford the target aminopyrimidine derivative.
【1】 Feurer, A.; et al.; 3-(2-Pyrimidinyl)pyrazolo[3,4-b]pyridines: A novel class of orally active NO-independent stimulators of soluble guanylate cyclase. 222nd ACS Natl Meet (Aug 26 2001, Chicago) 2001, Abst MEDI 205. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 16824 | 2-cyclopropylacetonitrile; Cyclopropylacetonitrile | 6542-60-5 | C5H7N | 详情 | 详情 |
(II) | 45474 | methyl formate | 107-31-3 | C2H4O2 | 详情 | 详情 |
(III) | 63160 | (Z)-2-cyclopropyl-3-hydroxy-2-propenenitrile | C6H7NO | 详情 | 详情 | |
(IV) | 50477 | 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide | 256376-68-8 | C14H12FN5 | 详情 | 详情 |
Extended Information