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【结 构 式】 
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【分子编号】56527 【品名】1,6,9,12-tetraoxo-1-phenyl-4-thia-2,7,10,13-tetraazapentadecan-15-oic acid 【CA登记号】 |
【 分 子 式 】C16H20N4O6S 【 分 子 量 】396.42416 【元素组成】C 48.48% H 5.09% N 14.13% O 24.22% S 8.09% |
合成路线1
该中间体在本合成路线中的序号：(XII)Other S-protecting groups for mercaptoacetyl triglycine have been reported. The S-benzyl derivative (X) was prepared by condensation of triglycine (I) with (benzylthio)acetyl chloride (IX). Alternatively, the S-benzamidomethyl compound (XII) was prepared as follows. Thioglycolic acid (V) was condensed with benzamidomethanol under acidic conditions to give S-(benzamidomethyl)thioglycolic acid (XI), which was then coupled to triglycine (I) using DCC/HOBt. Deprotection in the presence of 99Tc pertechnetate under the same conditions as above furnished the title Tc complex.
| 【1】 Okarvi, S.M.; et al.; Comparison of the labelling characteristics of mercaptoacetyltriglycine (MAG3) with different S-protective groups. J Label Compd Radiopharm 1997, 39, 10, 853. |
| 【2】 Bormans, G.; et al.; Investigation of the labelling characteristics of 99mTc-mercaptoacetyltriglycine. Nucl Med Biol 1995, 22, 3, 339. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 56518 | 2-({2-[(2-aminoacetyl)amino]acetyl}amino)acetic acid | C6H11N3O4 | 详情 | 详情 | |
| (V) | 18524 | 2-sulfanylacetic acid | 68-11-1 | C2H4O2S | 详情 | 详情 |
| (IX) | 56524 | 2-(benzylsulfanyl)acetyl chloride | C9H9ClOS | 详情 | 详情 | |
| (X) | 56525 | 4,7,10-trioxo-1-phenyl-2-thia-5,8,11-triazatridecan-13-oic acid | C15H19N3O5S | 详情 | 详情 | |
| (XI) | 56526 | 2-{[(benzoylamino)methyl]sulfanyl}acetic acid | C10H11NO3S | 详情 | 详情 | |
| (XII) | 56527 | 1,6,9,12-tetraoxo-1-phenyl-4-thia-2,7,10,13-tetraazapentadecan-15-oic acid | C16H20N4O6S | 详情 | 详情 |