(6R,7R)-7-amino-3-(1H-imidazo[1,2-b]pyridazin-4-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate -Drug Synthesis Database

【结构式】

【分子编号】56513

【品名】(6R,7R)-7-amino-3-(1H-imidazo[1,2-b]pyridazin-4-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

【CA登记号】

【分子式】C₁₄H₁₃N₅O₃S

【分子量】331.35512

【元素组成】C 50.75% H 3.95% N 21.14% O 14.49% S 9.68%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IX)

Alternatively, the title compound can be prepared by acylation of the imidazopyridazinium cephem derivative (IX) with acid chloride (II) in the presence of NaOAc.

参考文献中间体

合成目标

【1】 Hamamura, K.; Shinohara, H.; Kodama, M.; Kuroda, H. (Eisai Co., Ltd.); Process for the production of cephem cpds.. EP 0832893 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(II)	11758	2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetyl chloride		C₅H₅ClN₄O₂S	详情	详情
(IX)	56513	(6R,7R)-7-amino-3-(1H-imidazo[1,2-b]pyridazin-4-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate		C₁₄H₁₃N₅O₃S	详情	详情

Extended Information