ethyl 4-chloro-3-methoxy-2-pyridinecarboxylate -Drug Synthesis Database

【结构式】

【分子编号】56504

【品名】ethyl 4-chloro-3-methoxy-2-pyridinecarboxylate

【CA登记号】

【分子式】C₉H₁₀ClNO₃

【分子量】215.63604

【元素组成】C 50.13% H 4.67% Cl 16.44% N 6.5% O 22.26%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XVII)

A related method for the preparation of the intermediate 3,4-dimethoxy-2-(hydroxymethyl)pyridine (XII) has been disclosed. 3-Methoxypyridine (XV) was chlorinated to (XVI) by refluxing in SOCl2. Radical carboxylation of pyridine (XVI) was carried out by reaction with ethyl pyruvate in the presence of hydrogen peroxide and iron(II) sulfate. The resultant ethyl 4-chloro-3-methoxypicolinate (XVII) was then converted to the dimethoxypicolinate (XVIII) by treatment with sodium methoxide. Then, ester group reduction in (XVIII) by means of DIBAL provided the target hydroxymethyl pyridine (XII).

参考文献中间体

合成目标

【1】 Chen, L.; Zoghbi, M. (PDi-Research Laboratories, Inc. ); Synthesis of pharmaceutically useful pyridine derivs.. WO 9850361 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XII)	56501	(3,4-dimethoxy-2-pyridinyl)methanol		C₈H₁₁NO₃	详情	详情
(XV)	56502	3-Methoxypyridine	7295-76-3	C₆H₇NO	详情	详情
(XVI)	56503	4-chloro-3-methoxypyridine; 4-chloro-3-pyridinyl methyl ether		C₆H₆ClNO	详情	详情
(XVII)	56504	ethyl 4-chloro-3-methoxy-2-pyridinecarboxylate		C₉H₁₀ClNO₃	详情	详情
(XVIII)	14039	methyl 3,4-dimethoxy-2-pyridinecarboxylate		C₉H₁₁NO₄	详情	详情

Extended Information