3-methoxy-4-pyridinylamine; 3-methoxy-4-pyridinamine -Drug Synthesis Database

【结构式】

【分子编号】53287

【品名】3-methoxy-4-pyridinylamine; 3-methoxy-4-pyridinamine

【CA登记号】n/a

【分子式】C₆H₈N₂O

【分子量】124.1424

【元素组成】C 58.05% H 6.5% N 22.57% O 12.89%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The condensation of 4-amino-5-chloro-2-methoxybenzoic acid (I) with 3-methoxypyridine-4-amine (II) by means of ethyl chloroformate and DEA in chloroform gives the corresponding amide (III), which is condensed with 3-(4-fluorophenoxy)propyl chloride (IV) by means of phenol in hot toluene to yield the pyridinium chloride (V). Finally, this compound is hydrogenated with H2 over PtO2/C in ethanol containing NaHCO3 to afford the target cisapride.

参考文献中间体

合成目标

【1】 Van Daele, G.H.P. (Janssen Pharmaceutica NV); ES 2007259 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12419	4-Amino-5-chloro-2-methoxybenzoic acid	7206-70-4	C₈H₈ClNO₃	详情	详情
(II)	53287	3-methoxy-4-pyridinylamine; 3-methoxy-4-pyridinamine	n/a	C₆H₈N₂O	详情	详情
(III)	53288	4-amino-5-chloro-2-methoxy-N-(3-methoxy-4-pyridinyl)benzamide	n/a	C₁₄H₁₄ClN₃O₃	详情	详情
(IV)	30524	3-chloropropyl 4-fluorophenyl ether; 1-(3-chloropropoxy)-4-fluorobenzene; 1-(4-Fluorophenoxy)-3-chloropropane	1716-42-3	C₉H₁₀ClFO	详情	详情
(V)	53289	4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-[3-(4-fluorophenoxy)propyl]-3-methoxypyridinium chloride	n/a	C₂₃H₂₄Cl₂FN₃O₄	详情	详情

Extended Information