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【结 构 式】

【分子编号】53127

【品名】4-(1,3-dioxolan-2-yl)aniline; 4-(1,3-dioxolan-2-yl)phenylamine

【CA登记号】n/a

【 分 子 式 】C9H11NO2

【 分 子 量 】165.19188

【元素组成】C 65.44% H 6.71% N 8.48% O 19.37%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The precursor aldehyde (VI) was prepared as follows. 4-Nitrobenzaldehyde (I) was protected as the ethylene acetal (II) and subsequently reduced by catalytic hydrogenation in the presence of PtO2 to furnish aniline (III). Acylation of (III) with 2-thiophenecarbonyl chloride (IV) provided amide (V). The ethylene acetal group of (V) was then hydrolyzed to the target aldehyde (VI) under acidic conditions.

1 Folkes, A.; et al.; Synthesis and in vitro evaluation of a series of diketopiperazine inhibitors of plasminogen activator inhibitor-1. Bioorg Med Chem Lett 2001, 11, 19, 2589.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 18184 4-Nitrobenzaldehyde 555-16-8 C7H5NO3 详情 详情
(II) 53126 2-(4-nitrophenyl)-1,3-dioxolane n/a C9H9NO4 详情 详情
(III) 53127 4-(1,3-dioxolan-2-yl)aniline; 4-(1,3-dioxolan-2-yl)phenylamine n/a C9H11NO2 详情 详情
(IV) 14103 2-Thiophenecarbonyl chloride 5271-67-0 C5H3ClOS 详情 详情
(V) 53128 N-[4-(1,3-dioxolan-2-yl)phenyl]-2-thiophenecarboxamide n/a C14H13NO3S 详情 详情
(VI) 53129 N-(4-formylphenyl)-2-thiophenecarboxamide n/a C12H9NO2S 详情 详情
Extended Information