4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzenesulfonyl chloride -Drug Synthesis Database

【结构式】

【分子编号】53125

【品名】4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzenesulfonyl chloride

【CA登记号】n/a

【分子式】C₁₄H₈ClNO₄S

【分子量】321.74056

【元素组成】C 52.26% H 2.51% Cl 11.02% N 4.35% O 19.89% S 9.97%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

The condensation of phthalic anhydride (I) with aniline (II) in refluxing HOAc produced N-phenyl phthalimide (III). Aromatic sulfonation of (III) with chlorosulfonic acid in the presence of PCl5 afforded the sulfonyl chloride (IV). This was finally condensed with thiomorpholine (V) to furnish the target sulfonamide.

参考文献中间体

合成目标

【1】 Legora, A.M.; et al.; Anti-inflammatory effects of thalidomide-derived compounds on LPS-induced inflammation in mouse lung. Inflamm Res 2001, 50, Suppl. 3, Abst 083.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11900	2-Benzofuran-1,3-dione;1,2-Benzenedicarboxylic Anhydride;1,2-BENZENE DICARBOXYLIC ACID ANHYDRIDE;1,2-BENZENEDICARBONIC ACID, ANHYDRIDE;1,3-DIOXOPHTHALAN;1,3-ISOBENZOFURANDIONE;o-phthalic anhydride; Phthalic anhydride	85-44-9	C₈H₄O₃	详情	详情
(II)	12294	Aniline; Phenylamine	62-53-3	C₆H₇N	详情	详情
(III)	53124	N-Phenylphthalimide	520-03-6	C₁₄H₉NO₂	详情	详情
(IV)	53125	4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzenesulfonyl chloride	n/a	C₁₄H₈ClNO₄S	详情	详情
(V)	36317	thiomorpholine	123-90-0	C₄H₉NS	详情	详情

Extended Information