2-fluoro-5-nitrobenzoyl chloride -Drug Synthesis Database

【结构式】

【分子编号】52997

【品名】2-fluoro-5-nitrobenzoyl chloride

【CA登记号】n/a

【分子式】C₇H₃ClFNO₃

【分子量】203.5568632

【元素组成】C 41.3% H 1.49% Cl 17.42% F 9.33% N 6.88% O 23.58%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

2-Fluoro-5-nitrobenzoic acid (I) was converted to the corresponding acid chloride (II) by chlorination of with SOCl2. Condensation of acid chloride (II) with 3,4-dimethoxybenzylamine (III) provided amide (IV). The aromatic fluorine atom of (IV) was then displaced with (R)-2-amino-1-propanol (V) in hot pyridine to furnish the title anthranilic acid derivative.

参考文献中间体

合成目标

【1】 Oku, T.; Sawada, K.; Kuroda, A.; Kayakiri, N.; Sawada, Y.; Inoue, T.; Mizutani, T. (Fujisawa Pharmaceutical Co., Ltd.); Anthranilic acid derivs. as inhibitors of the cGMP-phosphodiesterase. EP 1080069; JP 2001508811; US 6384080; WO 9954284 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	52996	2-Fluoro-5-nitrobenzoic acid	320-98-9	C₇H₄FNO₄	详情	详情
(II)	52997	2-fluoro-5-nitrobenzoyl chloride	n/a	C₇H₃ClFNO₃	详情	详情
(III)	13920	(3,4-Dimethoxyphenyl)methanamine; 3,4-Dimethoxybenzylamine; Veratrylamine	5763-61-1	C₉H₁₃NO₂	详情	详情
(IV)	52998	N-(3,4-dimethoxybenzyl)-2-fluoro-5-nitrobenzamide	n/a	C₁₆H₁₅FN₂O₅	详情	详情
(V)	21414	(2R)-2-Amino-1-propanol; D-Alaninol; D-(-)-Alaninol	35320-23-1	C₃H₉NO	详情	详情

Extended Information