(2R)-2-[(2-(acetylamino)-6-{[(diphenylamino)carbonyl]oxy}-9H-purin-9-yl)methyl]-4,4-diethoxybutyl acetate -Drug Synthesis Database

【结构式】

【分子编号】52988

【品名】(2R)-2-[(2-(acetylamino)-6-{[(diphenylamino)carbonyl]oxy}-9H-purin-9-yl)methyl]-4,4-diethoxybutyl acetate

【CA登记号】n/a

【分子式】C₃₁H₃₆N₆O₇

【分子量】604.66308

【元素组成】C 61.58% H 6% N 13.9% O 18.52%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XLIII)

Yet another method was based on the alkylation of 2-N-acetyl-6-O-diphenylcarbamoylguanine (XLII) with tosylate (XXII) to give (XLIII). This was hydrolyzed to the precursor (XXV) by treatment with KOH.

参考文献中间体

合成目标

【1】 Synthesis of acyclic nucleoside derivs.. WO 0008025 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XXII)	52971	(2S)-4,4-diethoxy-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)butyl acetate		C₁₈H₂₈O₇S	详情	详情
(XXV)	52974	2-amino-9-[(2R)-4,4-diethoxy-2-(hydroxymethyl)butyl]-1,9-dihydro-6H-purin-6-one		C₁₄H₂₃N₅O₄	详情	详情
(XLII)	37775	2-(acetamido)-9H-purin-6-yl diphenylcarbamate		C₂₀H₁₆N₆O₃	详情	详情
(XLIII)	52988	(2R)-2-[(2-(acetylamino)-6-{[(diphenylamino)carbonyl]oxy}-9H-purin-9-yl)methyl]-4,4-diethoxybutyl acetate	n/a	C₃₁H₃₆N₆O₇	详情	详情

Extended Information