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【结 构 式】 
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【分子编号】52963 【品名】4-nitrophenyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoate 【CA登记号】 |
【 分 子 式 】C19H20N2O6 【 分 子 量 】372.37768 【元素组成】C 61.28% H 5.41% N 7.52% O 25.78% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XI)A related method was based in the acylation of the diol precursor (VI) with the p-nitrophenyl ester of N-Cbz-L-valine (XI) to afford the valyl ester (XII), which was further esterified with stearoyl chloride (IX). The resultant N-Cbz diester (XIII) was finally deprotected by hydrogenolysis over Pd/C.
| 【1】 Engelhardt, P.; Hoberg, M.; Zhou, X.-X.; Lindborg, B.; Johansson, N.G. (Medivir AB); Acyclic nucleoside derivs.. EP 0888348; JP 2000504720; JP 2000504721; US 5869493; WO 9730051; WO 9730052 . |
| 【2】 Synthesis of acyclic nucleoside derivs.. WO 9834917 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 52959 | 2-amino-9-[(2R)-4-hydroxy-2-(hydroxymethyl)butyl]-1,9-dihydro-6H-purin-6-one | C10H15N5O3 | 详情 | 详情 | |
| (IX) | 52961 | n-Octadecanoyl chloride; Octadecanoyl Chloride; Stearic acid chloride; Stearoyl chloride | 112-76-5 | C18H35ClO | 详情 | 详情 |
| (XI) | 52963 | 4-nitrophenyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoate | C19H20N2O6 | 详情 | 详情 | |
| (XII) | 52964 | (3R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-(hydroxymethyl)butyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoate | C23H30N6O6 | 详情 | 详情 | |
| (XIII) | 52965 | (2R)-2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-4-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoyl)oxy]butyl stearate | C41H64N6O7 | 详情 | 详情 |
Extended Information