【结 构 式】 |
【分子编号】52935 【品名】Benzyl (2R)-2-pyrrolidinecarboxylate; D-Proline-benzylester hydrochloride 【CA登记号】 |
【 分 子 式 】C12H15NO2 【 分 子 量 】205.25664 【元素组成】C 70.22% H 7.37% N 6.82% O 15.59% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(I)The synthesis of Ro-63-8695 can be performed by first coupling of D-proline-benzylester hydrochloride (I) with adipoyl chloride (II) by means of Et3N in dichloromethane to furnish benzyl 1-[6-[2(R)-carboxy-1-pyrrolidinyl]-6-oxohexanoyl]pyrrolidine-2(R)-carboxylate (III), which is finally hydrogenated over Pd/C in MeOH.
【1】 Jacob-Roetne, R.; Hertel, C.; Hoffmann, T.; Norcross, R.D. (F. Hoffmann-La Roche AG); D-Proline derivs.. CA 2252163; EP 0915088; JP 1999209343; US 6262089 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 52935 | Benzyl (2R)-2-pyrrolidinecarboxylate; D-Proline-benzylester hydrochloride | C12H15NO2 | 详情 | 详情 | |
(II) | 52933 | Hexanedioyl dichloride; Adipoyl chloride | C6H8Cl2O2 | 详情 | 详情 | |
(III) | 52934 | Benzyl (2R)-1-(6-{(2R)-2-[(benzyloxy)carbonyl]pyrrolidinyl}-6-oxohexanoyl)-2-pyrrolidinecarboxylate; Benzyl 1-[6-[2(R)-carboxy-1-pyrrolidinyl]-6-oxohexanoyl]pyrrolidine-2(R)-carboxylate | C30H36N2O6 | 详情 | 详情 |
Extended Information