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【结 构 式】 
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【分子编号】52885 【品名】tert-butyl (2R,4R)-4-{[(tert-butoxycarbonyl)amino]methyl}-2-[({(1R)-3-phenyl-1-[(6-quinolinylamino)carbonyl]propyl}amino)carbonyl]-1-pyrrolidinecarboxylate 【CA登记号】 |
【 分 子 式 】C35H45N5O6 【 分 子 量 】631.7724 【元素组成】C 66.54% H 7.18% N 11.09% O 15.19% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XI)Coupling of N-Boc-D-benzylalanine (VII) and 6-aminoquinoline (VIII) by means of EDC provided amide (IX). After trifluoroacetic acid-promoted Boc group cleavage in (IX), the resultant amino amide (X) was coupled with the proline derivative (VI), yielding (XI). The Boc protecting groups of (XI) were finally removed by treatment with trifluoroacetic acid.
| 【1】 Renau, T.E.; et al.; Conformationally restricted analogs of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa. 41st Intersci Conf Antimicrob Agents Chemother (Dec 16 2001, Chicago) 2001, Abst F-341. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 52881 | (2R,4R)-1-(tert-butoxycarbonyl)-4-{[(tert-butoxycarbonyl)amino]methyl}-2-pyrrolidinecarboxylic acid | C16H28N2O6 | 详情 | 详情 | |
| (VII) | 52886 | Boc-(-)-alpha-amino-4-phenylbutyric acid; Boc-D-Homophenylalanine | 82732-07-8 | C15H21NO4 | 详情 | 详情 |
| (VIII) | 52882 | 6-Aminoquinoline; 6-Quinolinamine | 580-15-4 | C9H8N2 | 详情 | 详情 |
| (IX) | 52883 | tert-butyl (1R)-3-phenyl-1-[(6-quinolinylamino)carbonyl]propylcarbamate | C24H27N3O3 | 详情 | 详情 | |
| (X) | 52884 | (2R)-2-amino-4-phenyl-N-(6-quinolinyl)butanamide | C19H19N3O | 详情 | 详情 | |
| (XI) | 52885 | tert-butyl (2R,4R)-4-{[(tert-butoxycarbonyl)amino]methyl}-2-[({(1R)-3-phenyl-1-[(6-quinolinylamino)carbonyl]propyl}amino)carbonyl]-1-pyrrolidinecarboxylate | C35H45N5O6 | 详情 | 详情 |
Extended Information