|
【结 构 式】 
|
【分子编号】52568 【品名】3-(6-iodo-6-heptenoyl)-4-(phenylmethyl)-1,3-oxazolidin-2-one 【CA登记号】 |
【 分 子 式 】C17H20INO3 【 分 子 量 】413.25521 【元素组成】C 49.41% H 4.88% I 30.71% N 3.39% O 11.61% |
合成路线1
该中间体在本合成路线中的序号：(VIII)The chiral iodovinyl derivative (IX) has been obtained as follows: The chiral alkyne (VII) is treated with trimethylsilyl chloride and NaI to give the iodovinyl compound (VIII), which is finally enantioselectively methylated with NaHMDS and methyl iodide to afford the target iodovinyl compound (IX).
| 【1】 Chen, Y.; Taylor, R.E.; Total synthesis of epothilones B and D. Org Lett 2001, 3, 14, 2221. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VII) | 52567 | 3-(6-heptynoyl)-4-(phenylmethyl)-1,3-oxazolidin-2-one | C17H19NO3 | 详情 | 详情 | |
| (VIII) | 52568 | 3-(6-iodo-6-heptenoyl)-4-(phenylmethyl)-1,3-oxazolidin-2-one | C17H20INO3 | 详情 | 详情 | |
| (IX) | 52569 | 3-(6-iodo-2-methyl-6-heptenoyl)-4-(phenylmethyl)-1,3-oxazolidin-2-one | C18H22INO3 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(VIII)The chiral iodovinyl derivative (IX) has been obtained as follows: The chiral alkyne (VII) is treated with trimethylsilyl chloride and NaI to give the iodovinyl compound (VIII), which is finally enantioselectively methylated with NaHMDS and methyl iodide to afford the target iodovinyl compound (IX).
| 【1】 Chen, Y.; Taylor, R.E.; Total synthesis of epothilones B and D. Org Lett 2001, 3, 14, 2221. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VII) | 52567 | 3-(6-heptynoyl)-4-(phenylmethyl)-1,3-oxazolidin-2-one | C17H19NO3 | 详情 | 详情 | |
| (VIII) | 52568 | 3-(6-iodo-6-heptenoyl)-4-(phenylmethyl)-1,3-oxazolidin-2-one | C17H20INO3 | 详情 | 详情 | |
| (IX) | 52569 | 3-(6-iodo-2-methyl-6-heptenoyl)-4-(phenylmethyl)-1,3-oxazolidin-2-one | C18H22INO3 | 详情 | 详情 |