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【结 构 式】

【分子编号】52518

【品名】(3,5-dimethylphenyl)lithium

【CA登记号】

【 分 子 式 】C8H9Li

【 分 子 量 】112.10046

【元素组成】C 85.72% H 8.09% Li 6.19%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

The intermediate ketone (VI) was prepared as follows: 2-Methylcyclopropanecarboxylic acid (I) was converted to the Weinreb amide (III) via activation as the corresponding acid chloride (II) followed by reaction with N,O-dimethylhydroxylamine. The organolithium reagent (V), prepared by metalation of 5-bromo-m-xylene (IV) with n-BuLi, was then added to the methoxy amide (III), producing the target aryl cyclopropyl ketone (VI).

1 Chu, L.; Wyvratt, M.J.; Ponpipom, M.M.; Lin, P.; Ashton, W.T.; Goulet, M.; Young, J.; Girotra, N.N.; Fisher, M.H. (Merck & Co., Inc.); Antagonists of gonadotropin releasing hormone. EP 1095038; WO 0004013 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 52514 2-Methylcyclopropanecarboxylic acid 29555-02-0 C5H8O2 详情 详情
(II) 52515 2-methylcyclopropanecarbonyl chloride C5H7ClO 详情 详情
(III) 52516 N,2-dimethyl-N-(methyloxy)cyclopropanecarboxamide C7H13NO2 详情 详情
(IV) 52517 5-Bromo-1,3-dimethylbenzene; 5-Bromo-m-xylene; 1-Bromo-3,5-dimethylbenzene; 3,5-Dimethylbromobenzene 556-96-7 C8H9Br 详情 详情
(V) 52518 (3,5-dimethylphenyl)lithium C8H9Li 详情 详情
(VI) 52519 (3,5-dimethylphenyl)(2-methylcyclopropyl)methanone C13H16O 详情 详情
Extended Information