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【结 构 式】 
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【分子编号】52491 【品名】2-methyl-4-(methyloxy)-6-[(4-nitrophenyl)oxy]tetrahydro-2H-pyran-3,5-diol 【CA登记号】 |
【 分 子 式 】C13H17NO7 【 分 子 量 】299.28052 【元素组成】C 52.17% H 5.73% N 4.68% O 37.42% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)Regioselective O-methylation of p-nitrophenyl-beta-L-fucopyranoside (VII) by means of dibutyltin oxide and iodomethane provided the 3-O-methyl pyranoside (VIII). Subsequent catalytic hydrogenation of the nitro group of (VIII) over PtO2 gave aniline (IX), which was further converted to the isothiocyanate (X) upon treatment with thiophosgene and ethyl diisopropylamine. Finally, coupling between isothiocyanate (X) and amine (VI) furnished the target thiourea adduct, which was finally isolated as the corresponding hydrochloride salt.
| 【1】 Lerchen, H.-G.; et al.; Design and optimization of 20-O-linked camptothecin glyconjugates as anticancer agents. J Med Chem 2001, 44, 24, 4186. |
| 【2】 Baumgarten, J.; Von dem Bruch, K.; Lerchen, H.-G.; Sperzel, M. (Bayer AG); 20(S) Camptothecin glycoconjugates. DE 19801037; DE 19813137; EP 0981542; JP 2001526661; WO 9851703 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 52489 | 4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl 2-{[2-amino-3-(1H-imidazol-5-yl)propanoyl]amino}-3-methylbutanoate | C31H32N6O6 | 详情 | 详情 | |
| (VII) | 52490 | 2-methyl-6-[(4-nitrophenyl)oxy]tetrahydro-2H-pyran-3,4,5-triol | C12H15NO7 | 详情 | 详情 | |
| (VIII) | 52491 | 2-methyl-4-(methyloxy)-6-[(4-nitrophenyl)oxy]tetrahydro-2H-pyran-3,5-diol | C13H17NO7 | 详情 | 详情 | |
| (IX) | 52492 | 2-[(4-aminophenyl)oxy]-6-methyl-4-(methyloxy)tetrahydro-2H-pyran-3,5-diol | C13H19NO5 | 详情 | 详情 | |
| (X) | 52493 | 2-[(4-isothiocyanatophenyl)oxy]-6-methyl-4-(methyloxy)tetrahydro-2H-pyran-3,5-diol | C14H17NO5S | 详情 | 详情 |
Extended Information