【结 构 式】 |
【分子编号】52406 【品名】 【CA登记号】 |
【 分 子 式 】C76H135IO15SSi5 【 分 子 量 】1588.29687 【元素组成】C 57.47% H 8.57% I 7.99% O 15.11% S 2.02% Si 8.84% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号:(XLIV)Dess-Martin oxidation of both alcohol functions of (XLIII) yielded the keto sulfone (XLIV). Reductive cleavage of the phenylsulfonyl group (XLIV) to afford (XXXVIII) was carried out by means of an in situ-generated SmI2 solution in THF.
【1】 Littlefield, B.A.; Zheng, W.; Seletsky, B.M.; Yu, M.J.; Palme, M.H.; Towle, M.J. (Eisai Co., Ltd.); Macrocyclic analogs and methods of their use and preparation. US 6214865; WO 9965894 . |
合成路线2
该中间体在本合成路线中的序号:(XLIV)Dess-Martin oxidation of both alcohol functions of (XLIII) yielded the keto sulfone (XLIV). Reductive cleavage of the phenylsulfonyl group of (XLIV) to afford (XXXVIII) was carried out by means of an in situ-generated SmI2 solution in THF.
【1】 Littlefield, B.A.; Zheng, W.; Seletsky, B.M.; Yu, M.J.; Palme, M.H.; Towle, M.J. (Eisai Co., Ltd.); Macrocyclic analogs and methods of their use and preparation. US 6214865; WO 9965894 . |
Extended Information