• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】52344

【品名】2,6-Dichlorophenyl isothiocyanate

【CA登记号】6590-95-0

【 分 子 式 】C7H3Cl2NS

【 分 子 量 】204.07896

【元素组成】C 41.2% H 1.48% Cl 34.74% N 6.86% S 15.71%

与该中间体有关的原料药合成路线共 4 条

合成路线1

该中间体在本合成路线中的序号:(VI)

Nucleophilic substitution of 2,6-dichloro-3-nitrobenzonitrile (I) with methylamine provided the 2-(methylamino) regioisomer (II). The remaining chloride was subsequently displaced with the potassium enolate of ethyl 2-methylacetoacetate (III), yielding adduct (IV). After catalytic hydrogenation of the nitro group of (IV), the resulting amine (V) was condensed with 2,6-dichlorophenyl isothiocyanate (VI) to produce thiourea (VII), which was further cyclized to the benzimidazole (VIII) upon desulfuration with mercuric oxide. Decarbethoxylation and simultaneous cyclization between keto and cyano groups of (VIII) under acidic conditions gave rise to the fused pyridone system (IX). Regioselective oxidation of one methyl group of (IX) using selenium dioxide in hot dioxan furnished aldehyde (X). To this was added the vinyl Grignard reagent (XI), producing the allyl alcohol (XII), which was further esterified to acetate (XIII) with acetic anhydride and triethylamine. Finally, palladium-catalyzed displacement of the acetate group of (XIII) with diethylamine, with concomitant double bond rearrangement, produced the title allylic amine.

1 Goldberg, D.; Cardozo, M.G.; Tschantz, M.A.; Moss, N.; Morwick, T.; Prokopowicz, A.S. III; Snow, R.J.; Patel, U.R.; Wang, X.-J.; Hammach, A.; Takahashi, H. (Boehringer Ingelheim Pharmaceuticals Inc.); Heterocyclic cpds. useful as inhibitors of tyrosine kinases. WO 0125238 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 52340 2,6-Dichloro-3-nitrobenzonitrile 5866-98-8 C7H2Cl2N2O2 详情 详情
(II) 52341 6-chloro-2-(methylamino)-3-nitrobenzonitrile C8H6ClN3O2 详情 详情
(III) 10362 ethyl 2-methyl-3-oxobutanoate; ethyl 2-methylacetoacetate 609-14-3 C7H12O3 详情 详情
(IV) 52342 ethyl 2-[2-cyano-3-(methylamino)-4-nitrophenyl]-2-methyl-3-oxobutanoate C15H17N3O5 详情 详情
(V) 52343 ethyl 2-[4-amino-2-cyano-3-(methylamino)phenyl]-2-methyl-3-oxobutanoate C15H19N3O3 详情 详情
(VI) 52344 2,6-Dichlorophenyl isothiocyanate 6590-95-0 C7H3Cl2NS 详情 详情
(VII) 52345 ethyl 2-[2-cyano-4-({[(2,6-dichlorophenyl)amino]carbothioyl}amino)-3-(methylamino)phenyl]-2-methyl-3-oxobutanoate C22H22Cl2N4O3S 详情 详情
(VIII) 52346 ethyl 2-{7-cyano-2-[(2,6-dichlorophenyl)amino]-1-methyl-1H-benzimidazol-6-yl}-2-methyl-3-oxobutanoate C22H20Cl2N4O3 详情 详情
(IX) 52347 2-[(2,6-dichlorophenyl)amino]-1,6,7-trimethyl-1,8-dihydro-9H-imidazo[4,5-h]isoquinolin-9-one C19H16Cl2N4O 详情 详情
(X) 52348 2-[(2,6-dichlorophenyl)amino]-1,6-dimethyl-9-oxo-8,9-dihydro-1H-imidazo[4,5-h]isoquinoline-7-carbaldehyde C19H14Cl2N4O2 详情 详情
(XI) 16524 bromo(vinyl)magnesium 1826-67-1 C2H3BrMg 详情 详情
(XII) 52349 2-[(2,6-dichlorophenyl)amino]-7-(1-hydroxy-2-propenyl)-1,6-dimethyl-1,8-dihydro-9H-imidazo[4,5-h]isoquinolin-9-one C21H18Cl2N4O2 详情 详情
(XIII) 52350 1-{2-[(2,6-dichlorophenyl)amino]-1,6-dimethyl-9-oxo-8,9-dihydro-1H-imidazo[4,5-h]isoquinolin-7-yl}-2-propenyl acetate C23H20Cl2N4O3 详情 详情

合成路线2

该中间体在本合成路线中的序号:(VI)

Nucleophilic substitution of 2,6-dichloro-3-nitrobenzonitrile (I) with methylamine provided the 2-(methylamino) regioisomer (II). The remaining chloride was subsequently displaced with the potassium enolate of ethyl 2-methylacetoacetate (III), yielding adduct (IV). After catalytic hydrogenation of the nitro group of (IV), the resulting amine (V) was condensed with 2,6-dichlorophenyl isothiocyanate (VI) to produce thiourea (VII), which was further cyclized to the benzimidazole (VIII) upon desulfuration with mercuric oxide. Decarbethoxylation and simultaneous cyclization between keto and cyano groups of (VIII) under acidic conditions gave rise to the fused pyridone system (IX). Regioselective oxidation of one methyl group of (IX) using selenium dioxide in hot dioxan furnished aldehyde (X). To this was added the vinyl Grignard reagent (XI), producing the allyl alcohol (XII), which was further esterified to acetate (XIII) with acetic anhydride and triethylamine. Finally, palladium-catalyzed displacement of the acetate group of (XIII) with dimethylamine, with concomitant double bond rearrangement, produced the title allylic amine.

1 Goldberg, D.; Cardozo, M.G.; Tschantz, M.A.; Moss, N.; Morwick, T.; Prokopowicz, A.S. III; Snow, R.J.; Patel, U.R.; Wang, X.-J.; Hammach, A.; Takahashi, H. (Boehringer Ingelheim Pharmaceuticals Inc.); Heterocyclic cpds. useful as inhibitors of tyrosine kinases. WO 0125238 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 52340 2,6-Dichloro-3-nitrobenzonitrile 5866-98-8 C7H2Cl2N2O2 详情 详情
(II) 52341 6-chloro-2-(methylamino)-3-nitrobenzonitrile C8H6ClN3O2 详情 详情
(III) 10362 ethyl 2-methyl-3-oxobutanoate; ethyl 2-methylacetoacetate 609-14-3 C7H12O3 详情 详情
(IV) 52342 ethyl 2-[2-cyano-3-(methylamino)-4-nitrophenyl]-2-methyl-3-oxobutanoate C15H17N3O5 详情 详情
(V) 52343 ethyl 2-[4-amino-2-cyano-3-(methylamino)phenyl]-2-methyl-3-oxobutanoate C15H19N3O3 详情 详情
(VI) 52344 2,6-Dichlorophenyl isothiocyanate 6590-95-0 C7H3Cl2NS 详情 详情
(VII) 52345 ethyl 2-[2-cyano-4-({[(2,6-dichlorophenyl)amino]carbothioyl}amino)-3-(methylamino)phenyl]-2-methyl-3-oxobutanoate C22H22Cl2N4O3S 详情 详情
(VIII) 52346 ethyl 2-{7-cyano-2-[(2,6-dichlorophenyl)amino]-1-methyl-1H-benzimidazol-6-yl}-2-methyl-3-oxobutanoate C22H20Cl2N4O3 详情 详情
(IX) 52347 2-[(2,6-dichlorophenyl)amino]-1,6,7-trimethyl-1,8-dihydro-9H-imidazo[4,5-h]isoquinolin-9-one C19H16Cl2N4O 详情 详情
(X) 52348 2-[(2,6-dichlorophenyl)amino]-1,6-dimethyl-9-oxo-8,9-dihydro-1H-imidazo[4,5-h]isoquinoline-7-carbaldehyde C19H14Cl2N4O2 详情 详情
(XI) 16524 bromo(vinyl)magnesium 1826-67-1 C2H3BrMg 详情 详情
(XII) 52349 2-[(2,6-dichlorophenyl)amino]-7-(1-hydroxy-2-propenyl)-1,6-dimethyl-1,8-dihydro-9H-imidazo[4,5-h]isoquinolin-9-one C21H18Cl2N4O2 详情 详情
(XIII) 52350 1-{2-[(2,6-dichlorophenyl)amino]-1,6-dimethyl-9-oxo-8,9-dihydro-1H-imidazo[4,5-h]isoquinolin-7-yl}-2-propenyl acetate C23H20Cl2N4O3 详情 详情

合成路线3

该中间体在本合成路线中的序号:(X)

Alkylation of (2-cyanophenyl)acetonitrile (I) with iodomethane under phase-transfer conditions leads to the alpha,alpha-dimethyl nitrile (II), which is further cyclized to imide (III) with 90% H2SO4. Subsequent nitration of homophthalimide (III) with HNO3/H2SO4 furnishes (IV) (1). Nitrophthalimide (IV) is reduced to the corresponding amine (V) by hydrogenation in the presence of Pd/C. This is then converted into acetamide (VI) by treatment with Ac2O. A second nitration reaction with cold HNO3 leads to the nitro amide (VII), which is further hydrolyzed with H2SO4 to the nitro amine (VIII). Hydrogenation of (VIII) over PtO2 furnishes diamine (IX). Coupling of (IX) with 2,6-dichlorophenyl isothiocyanate (X) gives thiourea (XI). Ring closure of amino thiourea (XI) to the benzimidazole derivative (XII) is carried out by treatment with DCC in refluxing THF. Partial reduction of the imide function of (XII) with NaBH4 in moist THF affords (XIII). Finally, rearrangement of (XIII) in concentrated H2SO4 at room temperature gives rise to the title compound (1,2).

1 Snow, R.J.; Cardozo, M.G.; Morwick, T.M.; Bussacca, C.A.; Dong, Y.; Eckner, R.J.; Jacober, S.; Jakes, S.; Kapadia, S.; Lukas, S.; Panzenbeck, M.; Peet, G.W.; Peterson, J.D.; Prokopowicz, A.S. III; Sellati, R.; Tolbert, R.M.; Tschantz, M.A.; Moss, N.; Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: A new class of inhibitors of lck kinase. J Med Chem 2002, 45, 16, 3394.
2 Goldberg, D.; Cardozo, M.G.; Tschantz, M.A.; Moss, N.; Morwick, T.; Prokopowicz, A.S. III; Snow, R.J.; Patel, U.R.; Wang, X.-J.; Hammach, A.; Takahashi, H. (Boehringer Ingelheim Pharmaceuticals Inc.); Heterocyclic cpds. useful as inhibitors of tyrosine kinases. WO 0125238 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 21593 2-(cyanomethyl)benzonitrile 3759-28-2 C9H6N2 详情 详情
(II) 65069 2-(1-cyano-1-methylethyl)benzonitrile C11H10N2 详情 详情
(III) 21594 4,4-dimethyl-1,3(2H,4H)-isoquinolinedione C11H11NO2 详情 详情
(IV) 65072 4,4-dimethyl-7-nitro-1,3(2H,4H)-isoquinolinedione C11H10N2O4 详情 详情
(V) 65071 7-amino-4,4-dimethyl-1,3(2H,4H)-isoquinolinedione C11H12N2O2 详情 详情
(VI) 65070 N-(4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-7-isoquinolinyl)acetamide C13H14N2O3 详情 详情
(VII) 65073 N-(4,4-dimethyl-8-nitro-1,3-dioxo-1,2,3,4-tetrahydro-7-isoquinolinyl)acetamide C13H13N3O5 详情 详情
(VIII) 65074 7-amino-4,4-dimethyl-8-nitro-1,3(2H,4H)-isoquinolinedione C11H11N3O4 详情 详情
(IX) 65075 7,8-diamino-4,4-dimethyl-1,3(2H,4H)-isoquinolinedione C11H13N3O2 详情 详情
(X) 52344 2,6-Dichlorophenyl isothiocyanate 6590-95-0 C7H3Cl2NS 详情 详情
(XI) 65077 N-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-7-isoquinolinyl)-N'-(2,6-dichlorophenyl)thiourea C18H16Cl2N4O2S 详情 详情
(XII) 65076 2-(2,6-dichloroanilino)-6,6-dimethyl-1H-imidazo[4,5-h]isoquinoline-7,9(6H,8H)-dione C18H14Cl2N4O2 详情 详情
(XIII) 65078 2-(2,6-dichloroanilino)-7-hydroxy-6,6-dimethyl-1,6,7,8-tetrahydro-9H-imidazo[4,5-h]isoquinolin-9-one C18H16Cl2N4O2 详情 详情

合成路线4

该中间体在本合成路线中的序号:(VII)

In an alternative method, 2,6-dichloro-3-nitrobenzonitrile (I) is heated with ethanolic ammonia in a sealed vessel to produce the 2-amino benzonitrile (II). Subsequent condensation of 2-amino-6-chloro-3-nitrobenzonitrile (II) with ethyl methylacetoacetate (III) in the presence of K2CO3 leads to the aryl methyl acetoacetate ester (IV). Decarboxylation and cyclization of (IV) under acidic conditions then produces isoquinolinone (V). Nitro group reduction in (V) with H2 and Pd/C leads to diamine (VI), which is further coupled with 2,6-dichlorophenyl isothiocyanate (VII), yielding thiourea (VIII). Finally, ring closure of amino thiourea (VIII) with DCC in hot DMF affords the target tricyclic compound (2).

1 Goldberg, D.; Cardozo, M.G.; Tschantz, M.A.; Moss, N.; Morwick, T.; Prokopowicz, A.S. III; Snow, R.J.; Patel, U.R.; Wang, X.-J.; Hammach, A.; Takahashi, H. (Boehringer Ingelheim Pharmaceuticals Inc.); Heterocyclic cpds. useful as inhibitors of tyrosine kinases. WO 0125238 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 52340 2,6-Dichloro-3-nitrobenzonitrile 5866-98-8 C7H2Cl2N2O2 详情 详情
(II) 65079 2-amino-6-chloro-3-nitrobenzonitrile C7H4ClN3O2 详情 详情
(III) 10362 ethyl 2-methyl-3-oxobutanoate; ethyl 2-methylacetoacetate 609-14-3 C7H12O3 详情 详情
(IV) 65080 ethyl 2-(3-amino-2-cyano-4-nitrophenyl)-2-methyl-3-oxobutanoate C14H15N3O5 详情 详情
(V) 65082 8-amino-3,4-dimethyl-7-nitro-1(2H)-isoquinolinone C11H11N3O3 详情 详情
(VI) 65081 7,8-diamino-3,4-dimethyl-1(2H)-isoquinolinone C11H13N3O 详情 详情
(VII) 52344 2,6-Dichlorophenyl isothiocyanate 6590-95-0 C7H3Cl2NS 详情 详情
(VIII) 65083 N-(8-amino-3,4-dimethyl-1-oxo-1,2-dihydro-7-isoquinolinyl)-N'-(2,6-dichlorophenyl)thiourea C18H16Cl2N4OS 详情 详情
Extended Information