1-[1-({2-[5-(formylamino)-6-oxo-2-phenyl-1(6H)-pyrimidinyl]acetyl}amino)-2-phenylethyl]-2-oxo-5-(2-pyridinyloxy)pentyl acetate -Drug Synthesis Database

【结构式】

【分子编号】52338

【品名】1-[1-({2-[5-(formylamino)-6-oxo-2-phenyl-1(6H)-pyrimidinyl]acetyl}amino)-2-phenylethyl]-2-oxo-5-(2-pyridinyloxy)pentyl acetate

【CA登记号】

【分子式】C₃₃H₃₃N₅O₇

【分子量】611.65452

【元素组成】C 64.8% H 5.44% N 11.45% O 18.31%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XXI)

Acidic Boc group cleavage from (XIX) produced amine (XX). This was converted to formamide (XXI) upon treatment with in situ-generated formic acetic anhydride. Selective hydrolysis of the acetate ester of (XXI) was then achieved by treatment with K2CO3 in MeOH. The resultant keto alcohol (XXII) was finally oxidized to the title diketone employing DMSO in the presence of EDC and pyridinium trifluoroacetate

参考文献中间体

合成目标

【1】 Doggrell, S.A.; Castaner, J.; NK-3201. Drugs Fut 2003, 28, 4, 323.
【2】 Suzuki, Y.; Ishida, K. (Nippon Kayaku Co., Ltd.); Novel acetamide derivs. and protease inhibitors. EP 0936216; US 6271238; WO 9809949 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(XIX)	52336	1-[1-({2-[5-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-6-oxo-2-phenyl-1(6H)-pyrimidinyl]acetyl}amino)-2-phenylethyl]-2-oxo-5-(2-pyridinyloxy)pentyl acetate	C₃₇H₄₁N₅O₈	详情	详情
(XX)	52337	1-[1-({2-[5-amino-6-oxo-2-phenyl-1(6H)-pyrimidinyl]acetyl}amino)-2-phenylethyl]-2-oxo-5-(2-pyridinyloxy)pentyl acetate	C₃₂H₃₃N₅O₆	详情	详情
(XXI)	52338	1-[1-({2-[5-(formylamino)-6-oxo-2-phenyl-1(6H)-pyrimidinyl]acetyl}amino)-2-phenylethyl]-2-oxo-5-(2-pyridinyloxy)pentyl acetate	C₃₃H₃₃N₅O₇	详情	详情
(XXII)	52339	2-[5-(formylamino)-6-oxo-2-phenyl-1(6H)-pyrimidinyl]-N-[2-hydroxy-3-oxo-1-(phenylmethyl)-6-(2-pyridinyloxy)hexyl]acetamide	C₃₁H₃₁N₅O₆	详情	详情

Extended Information