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【结 构 式】 
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【分子编号】52280 【品名】5-(1-decynyl)-1-(4-[(trimethylsilyl)oxy]-5-{[(trimethylsilyl)oxy]methyl}tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione 【CA登记号】 |
【 分 子 式 】C25H44N2O5Si2 【 分 子 量 】508.80584 【元素组成】C 59.02% H 8.72% N 5.51% O 15.72% Si 11.04% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The known 5-decynyl-2'-deoxyuridine (I) was protected as the bis-silyl ether (II) with chlorotrimethylsilane and triethylamine. Treatment of (II) with POCl3 and triazole produced the triazolyl derivative (III). Finally, reaction of (III) with thioacetic acid gave rise to the desired thienopyrimidine.
| 【1】 Brancale, A.; et al.; Bicyclic anti-VZV nucleosides: Thieno analogues retain full antiviral activity. Bioorg Med Chem Lett 2001, 11, 18, 2507. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 42586 | 5-(1-decynyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione | C19H28N2O5 | 详情 | 详情 | |
| (II) | 52280 | 5-(1-decynyl)-1-(4-[(trimethylsilyl)oxy]-5-{[(trimethylsilyl)oxy]methyl}tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione | C25H44N2O5Si2 | 详情 | 详情 | |
| (III) | 52281 | 5-(1-decynyl)-4-(1H-1,2,4-triazol-1-yl)-1-(4-[(trimethylsilyl)oxy]-5-{[(trimethylsilyl)oxy]methyl}tetrahydro-2-furanyl)-2(1H)-pyrimidinone | C27H45N5O4Si2 | 详情 | 详情 |
Extended Information