|
【结 构 式】 
|
【分子编号】52266 【品名】9H-fluoren-9-ylmethyl 8-({4-[(2-{[1-(chloromethyl)-5-hydroxy-8-methyl-1,6-dihydropyrrolo[3,2-e]indol-3(2H)-yl]carbonyl}-1H-indol-5-yl)amino]-4-oxobutyl}oxy)-11-hydroxy-7-(methyloxy)-5-oxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-10 【CA登记号】 |
【 分 子 式 】C53H49ClN6O9 【 分 子 量 】949.4598 【元素组成】C 67.05% H 5.2% Cl 3.73% N 8.85% O 15.17% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIV)Acid (XII) was coupled with the indolyl amine (XIII) by means of EDC to give amide (XIV). Finally, simultaneous removal of the Fmoc protecting group of (XIV) and cyclization of its seco-cyclopropapyrroloindole moiety were accomplished in one step by treatment with tetrabutylammonium fluoride in DMF, producing the target compound.
| 【1】 Zhou, Q.; et al.; Design and synthesis of a novel DNA-DNA interstrand adenine-guanine cross-linking agent. J Am Chem Soc 2001, 123, 20, 4865. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XII) | 52264 | 4-{[10-{[(9H-fluoren-9-ylmethyl)oxy]carbonyl}-11-hydroxy-7-(methyloxy)-5-oxo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yl]oxy}butanoic acid | C32H32N2O8 | 详情 | 详情 | |
| (XIII) | 52265 | (5-amino-1H-indol-2-yl)[1-(chloromethyl)-5-hydroxy-8-methyl-1,6-dihydropyrrolo[3,2-e]indol-3(2H)-yl]methanone | C21H19ClN4O2 | 详情 | 详情 | |
| (XIV) | 52266 | 9H-fluoren-9-ylmethyl 8-({4-[(2-{[1-(chloromethyl)-5-hydroxy-8-methyl-1,6-dihydropyrrolo[3,2-e]indol-3(2H)-yl]carbonyl}-1H-indol-5-yl)amino]-4-oxobutyl}oxy)-11-hydroxy-7-(methyloxy)-5-oxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-10 | C53H49ClN6O9 | 详情 | 详情 |
Extended Information