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【结 构 式】 
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【分子编号】51985 【品名】10-Aminodecanoic acid 【CA登记号】13108-19-5 |
【 分 子 式 】C10H21NO2 【 分 子 量 】187.28228 【元素组成】C 64.13% H 11.3% N 7.48% O 17.09% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The silylation of 10-aminodecanoic acid with Tms-Cl in refluxing dichloromethane gives the bis-silylated compound (II), which is treated with acetylsalicyl chloride (III) and TEA to yield the salicylamide (IV). Finally, this compound is hydrolyzed with NaOH.
| 【1】 Baughman, R.A.; Salo-Kostmayer, S.; O'Toole, D.; Rosado-Gray, C.; Tai, M.; Mercogliano, F.; Leone-Bay, A.; Freeman, J.; Studies directed at the use of a parallel synthesis matrix to increase throughput in an in vivo assay. J Med Chem 2000, 43, 19, 3573. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 51985 | 10-Aminodecanoic acid | 13108-19-5 | C10H21NO2 | 详情 | 详情 |
| (II) | 51986 | trimethylsilyl 10-[(trimethylsilyl)amino]decanoate | C16H37NO2Si2 | 详情 | 详情 | |
| (III) | 16900 | 2-(chlorocarbonyl)phenyl acetate; Acetylsalicyloyl chloride | 5538-51-2 | C9H7ClO3 | 详情 | 详情 |
| (IV) | 51987 | trimethylsilyl 10-[[2-(acetoxy)benzoyl]amino]decanoate | C22H35NO5Si | 详情 | 详情 |
Extended Information