1-chloro-4-[(3-chloro-4-methoxybenzyl)amino]-6-phthalazinecarbonitrile -Drug Synthesis Database

【结构式】

【分子编号】51980

【品名】1-chloro-4-[(3-chloro-4-methoxybenzyl)amino]-6-phthalazinecarbonitrile

【CA登记号】

【分子式】C₁₇H₁₂Cl₂N₄O

【分子量】359.21404

【元素组成】C 56.84% H 3.37% Cl 19.74% N 15.6% O 4.45%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The condensation of the commercially available (Amersham) 14C-labeled 1-chloro-4-(3-chloro-4-methoxybenzylamino)phthalazine-6-carbonitrile (I) with 4-hydroxypiperidine (II) by means of K2CO3 and N-methyl-2-pyrrolidinone at 170 C yields the target phthalazine derivative.

参考文献中间体

合成目标

【1】 Watanabe, N.; et al.; Synthesis of 14C-labeled E4010. J Label Compd Radiopharm 2001, 44, 12, 843.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	51979	1-chloro-4-[(3-chloro-4-methoxybenzyl)amino]-6-phthalazinecarbonitrile		C₁₇H₁₂Cl₂N₄O	详情	详情
(I)	51980	1-chloro-4-[(3-chloro-4-methoxybenzyl)amino]-6-phthalazinecarbonitrile		C₁₇H₁₂Cl₂N₄O	详情	详情
(II)	12076	4-Piperidinol; 4-Hydroxypiperidine	5382-16-1	C₅H₁₁NO	详情	详情

Extended Information