di(tert-butyl) 1-phenethyl-2-(2-propynyl)-1,2-hydrazinedicarboxylate -Drug Synthesis Database

【结构式】

【分子编号】51938

【品名】di(tert-butyl) 1-phenethyl-2-(2-propynyl)-1,2-hydrazinedicarboxylate

【CA登记号】

【分子式】C₂₁H₃₀N₂O₄

【分子量】374.48028

【元素组成】C 67.35% H 8.07% N 7.48% O 17.09%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of fully Boc-protected 2-phenylethylhydrazine (I) with propargyl bromide (II) by means of NaH gives the protected disubstituted hydrazine (III), which is finally deprotected with 4N HCl in dioxane to afford the target hydrazine.

参考文献中间体

合成目标

【1】 Sloley, B.D.; Urichuk, L.J.; Pang, P.K.T.; Coutts, R.T.; Shan, J.J.; Baker, G.B.; Ling, L.; Synthesis of N-propargylphenelzine and analogues as neuroprotective agents. Bioorg Med Chem Lett 2001, 11, 20, 2715.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	51939	di(tert-butyl) 1-phenethyl-1,2-hydrazinedicarboxylate		C₁₈H₂₈N₂O₄	详情	详情
(II)	11176	3-Bromopropyne; 3-Bromo-1-propyne	106-96-7	C₃H₃Br	详情	详情
(III)	51938	di(tert-butyl) 1-phenethyl-2-(2-propynyl)-1,2-hydrazinedicarboxylate		C₂₁H₃₀N₂O₄	详情	详情

Extended Information