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【结 构 式】 
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【分子编号】51846 【品名】 【CA登记号】 |
【 分 子 式 】C14H20FeN2 【 分 子 量 】272.17128 【元素组成】C 61.78% H 7.41% Fe 20.52% N 10.29% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)The (dimethylaminomethyl)ferrocene (I) was metalated with butyllithium and the organolithium intermediate (II) was condensed with dimethylformamide to furnish, after aqueous quenching, the ferrocenecarboxaldehyde (III). Aldehyde (III) was converted to oxime (IV) by treatment with hydroxylamine in aqueous ethanol. Reduction of oxime (IV) using LiAlH4 produced the primary amine (V). This was then condensed with 4,7-dichloroquinoline (VI) in hot NMP, and the resulting adduct was finally isolated as the L-tartrate salt.
| 【1】 Domarle, O.; et al.; In vitro antimalarial activity of a new organometallic analog, ferrocene-chloroquine. Antimicrob Agents Chemother 1998, 42, 3, 540. |
| 【2】 Biot, C.; et al.; Synthesis an antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue. J Med Chem 1997, 40, 23, 3715. |
| 【3】 Lebibi, J.; Brocard, J.; Maciejewski, L. (Université des Sciences et Technologies de Lille - Lille 1); Antimalarial organometallic iron complexes. WO 9635698 . |
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