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【结 构 式】

【分子编号】51632

【品名】tert-butyl (1S)-1-[(hydroxyimino)methyl]-3-methylbutylcarbamate

【CA登记号】

【 分 子 式 】C11H22N2O3

【 分 子 量 】230.30736

【元素组成】C 57.37% H 9.63% N 12.16% O 20.84%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The isoxazolepropionate intermediate (IV) has been obtained as follows: The cyclization of N-(tert-butoxycarbonyl)-L-leucinal oxime (I) with 4-pentynoic acid methyl ester (II) by means of NaOCl and TEA in dichloromethane gives the protected isoxazole derivative (III), which is then treated with Cl in dioxane to afford the desired isoxazole intermediate (IV).

1 Duplantier, A.J.; et al.; Isoxazolyl, oxazolyl, and thiazolylpropionic acid derivatives as potent alpha4beta1 integrin antagonists. Bioorg Med Chem Lett 2001, 11, 19, 2593.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 51632 tert-butyl (1S)-1-[(hydroxyimino)methyl]-3-methylbutylcarbamate C11H22N2O3 详情 详情
(II) 51633 methyl 4-pentynoate C6H8O2 详情 详情
(III) 51634 methyl 3-(3-[(1S)-1-[(tert-butoxycarbonyl)amino]-3-methylbutyl]-5-isoxazolyl)propanoate C17H28N2O5 详情 详情
(IV) 51635 methyl 3-[3-[(1S)-1-amino-3-methylbutyl]-5-isoxazolyl]propanoate C12H20N2O3 详情 详情
Extended Information