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【结 构 式】

【分子编号】51556

【品名】1-[(2R,4S)-2-([[tert-butyl(dimethyl)silyl]oxy]methyl)-1,3-dioxolan-4-yl]-5-[(E)-2-chloroethenyl]-2,4(1H,3H)-pyrimidinedione

【CA登记号】

【 分 子 式 】C16H25ClN2O5Si

【 分 子 量 】388.92318

【元素组成】C 49.41% H 6.48% Cl 9.12% N 7.2% O 20.57% Si 7.22%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The condensation of the chiral dioxolane (I) with 5(E)-(2-chlorovinyl)uracil (II) by means of Tbdms-OTf and lutidine gives the silylated nucleoside (II) that is purified by chromatography. Finally, this compound is deprotected by means of TBAF in acetonitrile.

1 Gumina, G.; Li, L.; Lee, C.S.; Cheng, Y.-C.; Choi, Y.; Tsujii, E.; Grill, S.; Gullen, E.; Chu, C.K.; Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses. J Med Chem 2000, 43, 13, 2538.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 51553 (2R)-2-([[tert-butyl(dimethyl)silyl]oxy]methyl)-1,3-dioxolan-4-yl acetate C12H24O5Si 详情 详情
(II) 51555 5-[(E)-2-chloroethenyl]-2,4(1H,3H)-pyrimidinedione C6H5ClN2O2 详情 详情
(III) 51556 1-[(2R,4S)-2-([[tert-butyl(dimethyl)silyl]oxy]methyl)-1,3-dioxolan-4-yl]-5-[(E)-2-chloroethenyl]-2,4(1H,3H)-pyrimidinedione C16H25ClN2O5Si 详情 详情
Extended Information